catalog number :
MBS659922
products full name :
Enkephalin-Arg-Phe, Met (Tyr-Gly-Gly-Phe-Met-Arg-Phe)
products short name :
Enkephalin-Arg-Phe, Met
other names :
enkephalin; Proenkephalin-A; proenkephalin-A; proenkephalin 1; proenkephalin 2; preproenkephalin 2; proenkephalin related sequence; proenkephalin; Opioid growth factor
other gene names :
Penk; Penk; Enk; Penk1; Penk2; Penk-rs; Penk-rs; Penk1; OGF
uniprot entry name :
PENK_RAT
sequence :
Tyr-Gly-Gly-Phe-Met-Arg-Phe (Met-Enkephalin-Arg-Phe)
purity :
Highly Purified. ~95%. Purified by HPLC.
form :
Supplied as a lyophilized powder
storage stability :
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
Molecular Formula: C 42 H 56 N 10 O 9 S 1
products categories :
Molecular Biology; MB-Peptides
ncbi acc num :
AAA41115.1
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (828215); G Alpha (i) Signalling Events Pathway (828246); GPCR Downstream Signaling Pathway (828244); GPCR Ligand Binding Pathway (828214); Peptide Ligand-binding Receptors Pathway (828216); Signal Transduction Pathway (828062); Signaling By GPCR Pathway (828213)
ncbi summary :
neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006]
uniprot summary :
Function: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(239-260) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Ref.8. Subcellular location: Secreted. Tissue specificity: Expressed in brain, heart and testis. Post-translational modification: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. Sequence similarities: Belongs to the opioid neuropeptide precursor family. Mass spectrometry: Molecular mass is 2203.971 Da from positions 114 - 133. Determined by ESI. Ref.8Molecular mass is 4592.8 Da from positions 143 - 185. Determined by ESI. Ref.8Molecular mass is 2504.027 Da from positions 239 - 260. Determined by ESI. Ref.8