product summary
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company name :
MyBioSource
product type :
protein
product name :
Melittin
catalog :
MBS659880
quantity :
1 mg
price :
365 USD
more info or order :
product information
catalog number :
MBS659880
products type :
Peptide
products full name :
Melittin
products short name :
Melittin
other names :
melittin; Melittin; melittin; allergen Api m 3; allergen Api m III; melittin<; Allergen Api m 3; Allergen Api m III
other gene names :
Melt; MELT; GB10355
uniprot entry name :
MEL_APIME
host :
Synthetic peptide
purity :
96.49%
form :
Supplied as a lyophilized powder
storage stability :
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
Sequence (linear): Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2. Molecular Formula: C131H229N39O31
products categories :
Molecular Biology; MB-Peptides
ncbi gi num :
58585154
ncbi acc num :
NP_001011607.1
ncbi gb acc num :
NM_001011607.1
uniprot acc num :
P01501
ncbi mol weight :
2846.53
uniprot summary :
Function: Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. Ref.3Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin. Ref.3. Subunit structure: Monomer and homotetramer. Subcellular location: Secreted. Target cell membrane. Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey. Tissue specificity: Expressed by the venom gland. Allergenic properties: Causes an allergic reaction in human. Toxic dose: LC50 is 2.7 ug/ml against killifish. Ref.7. Miscellaneous: N-formyl-melittin major has 80% of the activity of melittin.Melittin: The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with phospholipase A2 variation, i.e. their production increase in the same months.Melittin-S: The secretion of this protein into venom follows a seasonal pattern, the maximum secretion occurring during the (southern) winter months. Sequence similarities: Belongs to the melittin family.
size1 :
1 mg
price1 :
365 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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