protein

PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) (human, ovine, rat) (Biotin)

MBS659266

5 mg

700 USD

Peptide

PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) (human, ovine, rat) (Biotin)

[PACAP-38]

[pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1; Pituitary adenylate cyclase-activating polypeptide type I receptor; pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; PACAP receptor 1; PACAP type I receptor; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I]

[ADCYAP1R1; ADCYAP1R1; PAC1; PAC1R; PACAPR; PACAPRI; PACAP type I receptor; PACAP-R-1; PACAP-R1]

PACR_HUMAN

95.25%

Supplied as a lyophilized powder. Labeled to Biotin

Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 6 months after receipt at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Sequence (linear): Biotin-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2. Molecular Formula: C2 13 H 345 N 65 O 55 S 2 . Source: Synthetic peptide

Molecular Biology; MB-Peptides

313851018

NP_001186564.1

NM_001199635.1

P41586

4760.66

Activation Of TRKA Receptors Pathway (106456); Circadian Entrainment Pathway (698773); Circadian Entrainment Pathway (699872); Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class B Secretin-like Pathway (198781); Glucagon-type Ligand Receptors Pathway (106380); Insulin Secretion Pathway (777534)

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Subunit structure: Interacts (via N-terminal extracellular domain) with ADCYAP1. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. Sequence similarities: Belongs to the G-protein coupled receptor 2 family. Sequence caution: The sequence BAA04466.1 differs from that shown. Reason: Erroneous initiation.

5 mg

700 USD