protein

Gastrin I, Big (human)

MBS658628

1 mg

505 USD

Peptide

Gastrin I, Big (human)

[Gastrin I, Big]

[gastrin preproprotein; Gastrin; gastrin; preprogastrin; gastrin; Gastrin component IGastrin-52; G52Big gastrin; Alternative name(s):; Gastrin component II; Gastrin-34; G34Gastrin; Alternative name(s):; Gastrin component III; Gastrin-17]

[GAST; GAST; GAS; GAS; G52; G34; G17; G14; G6]

GAST_HUMAN

Pyr-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

95.9%

Supplied as a white to off-white powder.

Lyophilized powder may be stored at 4°C for short-term only. Stable for 6 months at -20°C. Reconstitute (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Source: Synthetic peptide. Molecular Formula: C 176 H<SUB >251 N 43 O 53 S 1

Molecular Biology; MB-Peptides

In humans, gastrin is a hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the stomach, duodenum, and the pancreas. Its existence was first suggested in 1905 by the British physiologist John Sydney Edkins,[1][2] and gastrins were isolated in 1964 by Gregory and Tracy in Liverpool.[3] The GAS gene is located on the long arm of the seventeenth chromosome (17q21).[4] Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach. It is secreted into the bloodstream. Gastrin is found primarily in three forms: gastrin-34 ('big gastrin'), gastrin-17 ('little gastrin') and gastrin-14 ('minigastrin'). Also, pentagastrin, a five amino acid sequence artificially synthesized peptide, has a five amino acid sequence identical to the last five amino acid sequence at the C-terminus end of gastrin.

4503923

NP_000796.1

NM_000805.4

P01350

3849.28

G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]

Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Subcellular location: Secreted. Post-translational modification: Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Ref.13 Ref.14 Ref.15Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. Ref.13 Ref.14 Ref.15. Sequence similarities: Belongs to the gastrin/cholecystokinin family.

1 mg

505 USD