catalog number :
MBS653983
products full name :
Carboxypeptidase B
products short name :
Carboxypeptidase B
other names :
carboxypeptidase B preproprotein; Carboxypeptidase B; carboxypeptidase B; protaminase; procarboxypeptidase B; pancreas-specific protein; tissue carboxypeptidase B; pancreatic carboxypeptidase B; carboxypeptidase B1 (tissue); Pancreas-specific protein
other gene names :
CPB1; CPB1; CPB; PASP; PCPB; CPB; PCPB; PASP
uniprot entry name :
CBPB1_HUMAN
purity :
Molecular Biology Grade
form :
Chromatographically purified and supplied as a solution in 0.1M sodium chloride.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at - 20 degree C. Aliquots are stable for 6 months after receipt at -20 degree C. For maximum recovery or product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
CAS Number: 9025-24-5. Activity: > or = 170 units/mg protein. Chymotrypsin: None Detected. Carboxypeptidase A: 0.34%. Trypsin: 0.008%. Certificate of Origin: The raw animal product used in the manufacturing of Carboxypeptidase B is derived from materials originating in North America and collected in USDA approved facilities and inspected to be free of disease.
products categories :
Molecular Biology; MB-Enzymes, Carboxypeptidase
products description :
Carboxypeptidase B (CPB) catalyzes hydrolysis of the basic amino acids, lysine, arginine, and ornithine from the C-teminal position in polypeptides. It occurs as a zymogen in the pancreas of most vertebrates.
ncbi acc num :
NP_001862.2
ncbi gb acc num :
NM_001871.2
ncbi pathways :
Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Peptide Hormone Metabolism Pathway (771603); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)
ncbi summary :
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
uniprot summary :
Catalytic activity: Preferential release of a C-terminal lysine or arginine amino acid. Cofactor: Binds 1 zinc ion per subunit. Subcellular location: Secreted. Tissue specificity: Pancreas. Sequence similarities: Belongs to the peptidase M14 family.