protein

APOBEC3A (Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3A, APOBEC 3A, APOBEC-3A, ARP3, BEDP, bK150C2.1, Catalytic Polypeptide-like 3A, Phorbolin 1, PHO1, PHRBN) (Control Peptide)

MBS653979

0.1 mg

400 USD

Enzyme

APOBEC3A (Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3A, APOBEC 3A, APOBEC-3A, ARP3, BEDP, bK150C2.1, Catalytic Polypeptide-like 3A, Phorbolin 1, PHO1, PHRBN) (Control Peptide)

[APOBEC3A]

[APOBEC3A protein; DNA dC->dU-editing enzyme APOBEC-3A; DNA dC- dU-editing enzyme APOBEC-3A; phorbolin 1; phorbolin-1; probable DNA dC- dU-editing enzyme APOBEC-3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; Phorbolin-1]

[APOBEC3A; APOBEC3A; A3A; ARP3; PHRBN; bK150C2.1; A3A]

ABC3A_HUMAN

Synthetic

C-TSNFNNGIGRHKTY

Supplied as lyophilized powder from lyophilization of a solution containing 5pmol/ uL peptide in 5% acetronitrile/water. Reconstitute with 200 uL sterile water.

Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Suitable for use in ELISA (EIA) and Blocking Studies. Other applications not tested.

Note: Peptide has not been tested in blocking applications. Optimal dilutions to be determined by the researcher.

Molecular Biology; MB-Enzymes, Cytidine Deaminase (APOBEC)

Control peptide for MBS653979 (goat anti-human APOBEC3A antibody)

219520199

AAI44147.1

P31941

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Function: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Ref.1 Ref.8 Ref.9 Ref.11 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17 Ref.19 Ref.22 Ref.24. Catalytic activity: Cytidine + H2O = uridine + NH3. Ref.9 Ref.12 Ref.13 Ref.17. Cofactor: Zinc . By similarity. Subunit structure: Interacts with AGO2. Interacts with TRIB3 (via N-terminus). Ref.23 Ref.25. Subcellular location: Nucleus. Cytoplasm Ref.9 Ref.11 Ref.17 Ref.18 Ref.23. Tissue specificity: Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. Ref.6 Ref.9 Ref.13 Ref.14. Induction: Up-regulated by interferon and CpG single-stranded DNA (at protein level). Ref.12 Ref.13. Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Sequence similarities: Belongs to the cytidine and deoxycytidylate deaminase family.Contains 1 CMP/dCMP deaminase zinc-binding domain.

0.1 mg

400 USD