catalog number :
MBS653649
products full name :
a1-Antichymotrypsin, Human (AACT, Alpha1-ACT)
products short name :
[a1-Antichymotrypsin]
other names :
[alpha-1-antitrypsin]
form :
Supplied as a lyophilized powder from ammonium bicarbonate. Reconstitute with sterile PBS, pH >7.0.
storage stability :
Lyophilized powder may be stored at -20 degree C. Stable for 6 months after receipt at -20 degree C. Reconstitute with sterile PBS, pH >7.0. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For minimum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
tested application :
ELISA, Inhibition Assays, Western Blotting
app notes :
Optimal dilutions to be determined by researcher.
products categories :
Molecular Biology; MB-Enzymes
products description :
Alpha 1 ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1- ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.
ncbi acc num :
NP_001121179.1
ncbi gb acc num :
NM_001127707.1
ncbi pathways :
Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA1 Transcription Factor Network Pathway (137979); Hemostasis Pathway (106028); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)
ncbi summary :
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]