product summary
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company name :
MyBioSource
product type :
chemical
product name :
Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)
catalog :
MBS651229
quantity :
0.5 mg
price :
510 USD
more info or order :
product information
catalog number :
MBS651229
products type :
Antibiotic
products full name :
Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)
products short name :
Leptomycin B
host :
Streptomyces sp.
purity :
Highly Purified. >99% by HPLC
form :
Colorless film
storage stability :
Stable for 6 months at -20 degree C.
other info1 :
CAS Number: 87081-35-4. Molecular Formula: C33H48O6
other info2 :
Solubility: Soluble in ethanol or methanol. Poor water solubility. Ethanol is recommended. Unstable in DMSO.
products categories :
Biochemicals; Biochem-Antibiotics
products description :
Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, I B, MPF, MAP/ERK, MDM2/p53, NF- B/I B7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities.
ncbi mol weight :
540.7
size1 :
0.5 mg
price1 :
510 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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