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IP-10, Recombinant, Human (Interferon gamma Inducible Protein, CXCL10)

MBS651074

0.025 mg

340 USD

MBS651074

Recombinant Protein

IP-10, Recombinant, Human (Interferon gamma Inducible Protein, CXCL10)

IP-10

IP-10; C-X-C motif chemokine 10; C-X-C motif chemokine 10; gamma-IP10; OTTMUSP00000036425; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10; chemokine (C-X-C motif) ligand 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10

Cxcl10; Cxcl10; C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10; Crg2; Ifi10; Inp10; Scyb10

CXL10_MOUSE

E Coli

The first five N-terminal amino acids is Val-Pro-Leu-Ser-Arg.

Highly Purified. 98% as determined by RP-HPLC, and/or reducing and non-reducing SDS-PAGE Silver Stained gelEndotoxin:

Supplied as a lyophilized powder without additives. Reconstitute with sterile, ddH2O, 0.1% BSA or HSA to 100ug/ml

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Biological Activity: Recombinant Human IP-10 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human T lymphocytes at 10-100.0 ng/ml. Endotoxin Level: 0.1ng/ug (IEU/ug) of IP-10.

Growth Factors, Cytokines; Growth Factors-IP-10

Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto's thyroiditis, Graves'disease and Type 1 diabetes mellitus.The chemokine IP-10 (interferon-inducible protein of 10 kD, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. Recombinant Human IP-10 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8516 Dalton. Recombinant Human IP-10 is purified by proprietary chromatographic techniques.

976159

P17515

8.52kD

Chemokine Receptors Bind Chemokines Pathway 367053!!Chemokine Signaling Pathway 99271!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 367051!!Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytosolic DNA-sensing Pathway 125146!!Cytosolic DNA-sensing Pathway 124833!!G Alpha (i) Signalling Events Pathway 367079!!GPCR Downstream Signaling Pathway 367077

Function: In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development. Subcellular location: Secreted. Tissue specificity: Expressed in the spleen, thymus, lymph nodes and liver. Ref.5. Induction: By interferon gamma. Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

0.025 mg

340 USD