catalog number :
MBS651024
products type :
Recombinant Protein
products full name :
GRO/KC, Recombinant, Rat (Cxcl1, Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, alpha), Cinc1, CINC-1, C-X-C Motif Chemokine 1, Cytokine-induced Neutrophil Chemoattractant 1, Gro1, Growth-regulated alpha Protein, Platelet-derived
products short name :
GRO/KC, Rat
products name syn :
GRO/KC, Recombinant, Rat (Cxcl1, Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, alpha), Cinc1, CINC-1, C-X-C Motif Chemokine 1, Cytokine-induced Neutrophil Chemoattractant 1, Gro1, Growth-regulated alpha Protein, Platelet-derived
other names :
growth-regulated alpha protein; Growth-regulated alpha protein; growth-regulated alpha protein; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); chemokine (C-X-C motif) ligand 1; C-X-C motif chemokine 1; Cytokine-induced neutrophil chemoattractant 1; CINC-1; Platelet-derived growth factor-inducible protein KC
other gene names :
Cxcl1; Cxcl1; Gro1; CINC-1; Cinc1; Gro; Scyb1; CINC-1
uniprot entry name :
GROA_RAT
purity :
Molecular Biology Grade. 98% by SDS-PAGE and HPLC
form :
Supplied as a lyophilized powder. No additives. Reconstitute in sterile dH2O to 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.
storage stability :
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile water, aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
Biological Activity: Determined by ability to chemoattract total rat neutrophils at a concentration range of 10-100ng/ml. Endotoxin Level: 0.1ng/ug
products categories :
Growth Factors, Cytokines; Growth Factors-GRO
products description :
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8kD protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
ncbi acc num :
NP_110472.1
ncbi gb acc num :
NM_030845.1
ncbi pathways :
Chemokine Signaling Pathway (98755); Chemokine Signaling Pathway (96864); Cytokines And Inflammatory Response (BioCarta) Pathway (198521); Legionellosis Pathway (469194); Legionellosis Pathway (469186); NOD-like Receptor Signaling Pathway (122186); NOD-like Receptor Signaling Pathway (122131); Salmonella Infection Pathway (375168); Salmonella Infection Pathway (375149); Spinal Cord Injury Pathway (739006)
ncbi summary :
acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]
uniprot summary :
Function: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation. Subunit structure: Monomer and homodimer. Subcellular location: Secreted. Tissue specificity: At least expressed in the lung and trachea. Induction: By lipopolysaccharides (LPS) and inflammation. Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.