Resistin-like Molecule, alpha, Recombinant, Mouse (RELMa) | MyBioSource MBS650981 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Resistin-like Molecule, alpha, Recombinant, Mouse (RELMa)

catalog :

MBS650981

quantity :

0.005 mg

price :

345 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS650981

products type :

Recombinant Protein

products full name :

Resistin-like Molecule, alpha, Recombinant, Mouse (RELMa)

products short name :

[Resistin-like Molecule, alpha]

other names :

[resistin-like beta; Resistin-like beta; resistin-like beta; found in inflammatory zone 1; colon carcinoma-related gene protein; cysteine-rich secreted protein FIZZ2; cysteine-rich secreted A12-alpha-like protein 1; cysteine-rich secreted protein A12-alpha-like 1; colon and small intestine-specific cysteine-rich protein; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2; resistin like beta; Colon and small intestine-specific cysteine-rich protein; Colon carcinoma-related gene protein; Cysteine-rich secreted protein A12-alpha-like 1; Cysteine-rich secreted protein FIZZ2; RELMbeta]

other gene names :

[RETNLB; RETNLB; XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta; CCRG; FIZZ2; HXCP2; RETNL2]

uniprot entry name :

RETNB_HUMAN

host :

E Coli

sequence :

MKKLLFAIPL VVPFYSHSTM VNTDETIEII VENKVKELLA NPANYPSTVT TLSCTSVKT MNRWASCPAG MTATGCACGF ACGSWEIQSG DTCNCLCLLV DWTTARCCQL SLEDYKDDDD K

specificity :

The amino acid sequence of the recombinant Mouse RELM-alpha is 100% homologous to the amino acid sequence of the Mouse RELM-alpha.

purity :

Highly Purified. 95% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.

form :

Supplied as a lyophilized powder in 5mM Tris, pH 7.5, 25mM sodium chloride. Reconstitute with 200ul sterile ddH2O.

storage stability :

Lyophilized and reconstituted products are stable for 6 months after receipt at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the orginal vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

app notes :

Western blotting, ELISA

other info2 :

Solubility: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.

products categories :

Growth Factors, Cytokines; Growth Factors-Resistin

products description :

Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4kD cysteine-rich secreted protein, RELM-alpha (FIZZ1, found in inflammatory zone). RELM-alpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue stroma. Murine RELM-alpha (FIZZ1) is the founding member of a new gene family including two other murine genes expressed, respectively, in intestinal crypt epithelium (RELM-beta) and white adipose tissue (Resistin), and two related human genes. RELMalpha inhibits the differentiation of 3T3-L1 preadipocytes into adipocytes but has no effect on proliferation of 3T3-L1 preadipocytes. RELMalpha is able to form heterooligomers with resistin but not RELMbeta. Since RELMalpha is expressed by adipose tissue and it is a secreted factor, our findings suggest that RELMalpha may be involved in the control of the adipogenesis as well as in the process of muscle differentiation. In the lung, RELM-alpha is induced by hypoxia and was renamed as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) inhibited HIMF-activated Akt phosphorylation. It also inhibited HIMFstimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. Further studies showed that HIMF had angiogenic and vasoconstrictive properties. HIMF increased pulmonary arterial pressure and vascular resistence. Further studies suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation. Recombinant Mouse RELM-alpha is manufactured with a signal sequence of phage fd (20 amino acids) and C-terminal fusion of flagTag (10aa). The rmRELM-alpha Flag-Tagged Fusion Protein is a 13.3kD protein containing 91 amino acid residues with 30 additional amino acid residues-signal sequence of phage fd, flagTag.

ncbi gi num :

14211897

ncbi acc num :

NP_115968.1

ncbi gb acc num :

NM_032579.2

uniprot acc num :

Q9BQ08

ncbi mol weight :

13.3kD

ncbi pathways :

IL4-mediated Signaling Events Pathway (137933)

uniprot summary :

Function: Probable hormone. Subunit structure: Homodimer; disulfide-linked . By similarity. Subcellular location: Secreted. Tissue specificity: Expressed only in the gastrointestinal tract, particularly the colon. Sequence similarities: Belongs to the resistin/FIZZ family.

size1 :

0.005 mg

price1 :

345 USD

size2 :

0.025 mg

price2 :

420

more info or order :

MyBioSource product webpage