protein

Interleukin 6 Receptor, Recombinant, Human (IL-6R)

MBS650728

0.005 mg

275 USD

Recombinant Protein

Interleukin 6 Receptor, Recombinant, Human (IL-6R)

Interleukin 6 Receptor

interleukin-6-receptor; Interleukin-6 receptor subunit alpha; interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; OTTHUMP00000034320; OTTHUMP00000217867; OTTHUMP00000217870; membrane glycoprotein 80; IL-6 receptor subunit alpha; interleukin 6 receptor; IL-6R 1; Membrane glycoprotein 80

IL6R; IL6R; gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991

IL6RA_HUMAN

HEK 293 cells

Highly Purified. > or = 98% by SDS-PAGE and HPLC analyses

Supplied as a lyophilized powder from PBS, pH 7.2

Lyophilized powder may be stored at -20 degree C. Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Endotoxin Level: < or = 0.1ng/ug (1EU/ug)

Reconstitution: Reconstitute in PBS, pH 7.2 to a concentration of 0.1-1.0mg/ml. Biological Activity: The ED50 as determined by its' ability to intensify the IL-6induced groth inhibition of murin M1 cells is </= 5.0 ng/ml, in the presence of 20ng/ml of rhIL-6. Country of Origin: USA

Growth Factors, Cytokines; Growth Factors-Interleukin

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6kD protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).

32581

P08887

37.6kD

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-6 Signaling Pathway (198864); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-6 Signaling Pathway (205111); Jak-STAT Signaling Pathway (83077)

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14. Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST. Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14. Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum. Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Post-translational modification: A short soluble form may also be released from the membrane by proteolysis. Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

0.005 mg

275 USD

0.02 mg

340