Erythropoietin, Recombinant, Human (EPO) | MyBioSource MBS650641 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Erythropoietin, Recombinant, Human (EPO)

catalog :

MBS650641

quantity :

50 Units

price :

230 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS650641

products type :

Recombinant Protein

products full name :

Erythropoietin, Recombinant, Human (EPO)

products short name :

Erythropoietin

other names :

erythropoietin; Erythropoietin; erythropoietin; epoetin; OTTHUMP00000201234; erythropoietin

other gene names :

EPO; EP; MVCD2; MGC138142

uniprot entry name :

EPO_HUMAN

host :

cDNA obtained from human genes epressed in CHO

purity :

> or = 95%

form :

Supplied as a liquid in PBS

concentration :

5000 u/ml

storage stability :

For long-term storage, aliquot to avoid repeated freezing and thawing. Store at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

other info1 :

Specific Activity: ~100Ku/mg

other info2 :

Assay Used to Measure Bioactivity: Proliferation of reticulocytes in mouse blood is method used for unit measurement and calibrated to the World Health Organization (WHO) standard.

products categories :

Growth Factors, Cytokines; Growth Factors-EPO

products description :

Erythropoietin, ~34-36kD, normally produced in the kidney and liver, is the principle hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Indicated for treatment of neutropenia or anemia secondary to ZDV- or Ganciclovir-induced bone marrow suppression (most effective in patients with endogenous EPO levels < 500IU/ml).

ncbi gi num :

312304

uniprot acc num :

P01588

ncbi mol weight :

34-36kD

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

ncbi summary :

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq]

uniprot summary :

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular space; cell surface; extracellular region. Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity. Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; response to axon injury; positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; response to electrical stimulus; embryo implantation; positive regulation of DNA replication; aging. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2

size1 :

50 Units

price1 :

230 USD

size2 :

100 Units

price2 :

280

size3 :

500 Units

price3 :

710

more info or order :

MyBioSource product webpage