protein

Interleukin 6, Recombinant, Human (IL-6)

MBS650344

0.025 mg

515 USD

Recombinant Protein

Interleukin 6, Recombinant, Human (IL-6)

Interleukin 6

interleukin-6; Interleukin-6; interleukin-6; IL-6; Interleukin 6 (interferon, beta 2); interleukin 6

Il6; Il6; ILg6; Ifnb2; Il-6

IL6_RAT

Sf9

> 85% pure by SDS gel electrophoresis.

Supplied as a liquid in PBS

0.5 mg/ml

Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Shipping: Dry Ice

Biological Activity: 3H-thymidine uptake by B9 murine thymoma cell line that is IL-6 dependent. Endotoxin: <1ng/mg

Growth Factors, Cytokines; Growth Factors-Interleukin

Human Interleukin-6 (IL-6) plays a role in the mediation of the inflammatory and immune response initiated by infection or injury. IL-6 acts on B cells by stimulating differentiation and antibody secretion. IL-6 also exhibits growth factor activity for mature thymic or peripheral T cells, and enhances the differentiation of cytotoxic T cells in the presence of IL-2 or IFNt. This glycoprotein is composed of 184 aa residues, and has a 42% homology with murine IL-6.

7549769

NP_036721.1

NM_012589.1

P20607

20-21kD

Adipogenesis Pathway (198479); African Trypanosomiasis Pathway (194377); African Trypanosomiasis Pathway (194323); Amoebiasis Pathway (167311); Amoebiasis Pathway (167191); Androgen Receptor Signaling Pathway (198529); Chagas Disease (American Trypanosomiasis) Pathway (147806); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine-cytokine Receptor Interaction Pathway (83443); Cytokine-cytokine Receptor Interaction Pathway (460)

a cytokine involved in development and possibly in neurodegenerative processes [RGD]

Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Subcellular location: Secreted. Sequence similarities: Belongs to the IL-6 superfamily.

0.025 mg

515 USD