FGF-19 (Fibroblast Growth Factor 19) | MyBioSource MBS646770 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FGF-19 (Fibroblast Growth Factor 19)

catalog :

MBS646770

quantity :

0.05 mg

price :

440 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[FG369-1]

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS646770

products type :

Antibody

products full name :

FGF-19 (Fibroblast Growth Factor 19)

products short name :

[FGF-19]

products name syn :

[Anti -FGF-19 (Fibroblast Growth Factor 19)]

other names :

[fibroblast growth factor 19; Fibroblast growth factor 19; fibroblast growth factor 19; FGF-19; fibroblast growth factor 19]

other gene names :

[FGF19; FGF19; FGF-19]

uniprot entry name :

FGF19_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

[FG369-1]

host :

Mouse

specificity :

Recognizes human FGF-19. Detects a band of ~25kD by Western blot.

purity :

Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in PBS, pH 7.4. No preservative added.

concentration :

1mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

ELISA (Direct or Indirect): 1:2000-1:5000. Western Blot (WB): 1:2000-1:5000 using ECL, Suggested blocking and dilution buffer is PBST with 0.05% Tween-20, 5% skim milk; suggested incubation time is 1 hour at RT. Optimal dilutions to be determined by reseacher.

image1 heading :

Testing Data

other info1 :

Grade: Affinity Purified. Immunogen: Recombinant human FGF-19.

products categories :

Antibodies; Abs to Growth Factors, Cytokines

products description :

FGF-19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.

ncbi gi num :

4826726

ncbi acc num :

NP_005108.1

ncbi gb acc num :

NM_005117.2

uniprot acc num :

O95750

ncbi pathways :

Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957); FGF Signaling Pathway (137989); FGFR Ligand Binding And Activation Pathway (106344)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Ref.7 Ref.8 Ref.9 Ref.11. Subunit structure: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Ref.2 Ref.8 Ref.9 Ref.10 Ref.14. Subcellular location: Secreted. Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. Ref.2. Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2. Ref.7. Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4. Sequence similarities: Belongs to the heparin-binding growth factors family.

size1 :

0.05 mg

price1 :

440 USD

more info or order :

MyBioSource product webpage