LAG3 (Lymphocyte Activation Gene 3 Protein, LAG-3, Protein FDC, CD223, FDC) | MyBioSource MBS642763 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LAG3 (Lymphocyte Activation Gene 3 Protein, LAG-3, Protein FDC, CD223, FDC)

catalog :

MBS642763

quantity :

0.1 mg

price :

680 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

[12K124]

reactivity :

human, mouse

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Detection of LAG-3 in mouse pplenocytes by Flow Cytometry. Mouse splenocytes were treated for 72h with 50ng/ml PMA and 500ng/ml Ca2+ Ionomycin then stained with MBS642763 or isotype control antibody, followed by Allophycocyanin- conjugated Rat IgG Secondary Antibody.

product information

catalog number :

MBS642763

products type :

Antibody

products full name :

LAG3 (Lymphocyte Activation Gene 3 Protein, LAG-3, Protein FDC, CD223, FDC)

products short name :

[LAG3]

products name syn :

[Anti -LAG3 (Lymphocyte Activation Gene 3 Protein, LAG-3, Protein FDC, CD223, FDC)]

other names :

[lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Protein FDC]

other gene names :

[LAG3; LAG3; CD223; FDC; LAG-3]

uniprot entry name :

LAG3_HUMAN

clonality :

Monoclonal

isotype :

IgG2B

clone :

[12K124]

host :

Rat

reactivity :

Mouse

specificity :

Recognizes mouse LAG-3. Does not react with recombinant human LAG-3.

purity :

Affinity Purified. Purified by Protein G affinity chromatography from hybridoma culture supernatant.

form :

Supplied as a lyophilized powder from PBS pH7.4, 5% trehalose. Reconstitute with 200ul sterile PBS

concentration :

~0.5mg/ml after reconstitution

storage stability :

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

Flow Cytometry (FC/FACS)

app notes :

Suitable for use in Flow Cytometry. Dilution: Flow Cytometry: 2.5ug labels10e6 cells

image1 heading :

Flow Cytometry (FC/FACS)

other info1 :

Immunogen: Recombinant preotein corresponding to Ser23-Leu442 from mouse LAG-3 expressed in NS0 cell line.

other info2 :

Accession No: Q61790

products categories :

Antibodies; Abs to Growth Factors, Cytokines

products description :

LAG-3 is a member of the immunoglobulin superfamily (IgSF). The mature LAG-3 protein is a 496aa membrane protein with a 421aa extracellular region which contains four IgSF domains, a 21aa transmembrane region and a 54aa cytoplasmic region. LAG-3 shares <20% aa sequence homology with CD4, but has similar structure and binds to MHC class II with higher affinity. The mouse LAG-3 extracellular region shares 69% aa sequence identity with human LAG-3.

ncbi gi num :

167614500

ncbi acc num :

NP_002277.4

ncbi gb acc num :

NM_002286.5

uniprot acc num :

P18627

ncbi summary :

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

uniprot summary :

LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.32. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: transmembrane receptor activity; antigen binding; MHC class II protein binding. Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation

size1 :

0.1 mg

price1 :

680 USD

more info or order :

MyBioSource product webpage

company information

MyBioSource

P.O. Box 153308
San Diego, CA 92195-3308

sales@mybiosource.com

https://www.mybiosource.com

1-888-627-0165

headquarters: USA

MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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