product summary
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company name :
MyBioSource
product type :
protein
product name :
CENP-B, Recombinant, Human (Centromere Protein B)
catalog :
MBS638023
quantity :
0.005 mg
price :
345 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS638023
products type :
Recombinant Protein
products full name :
CENP-B, Recombinant, Human (Centromere Protein B)
products short name :
[CENP-B]
other names :
[CENP-B; Major centromere autoantigen B; Centromere protein B]
other gene names :
[CENPB; CENP-B]
uniprot entry name :
CENPB_HUMAN
host :
Sf9 insect cells
purity :
>95% (SDS-PAGE)
form :
Supplied as a liquid in 20mM HEPES buffer, pH 7.6, 250mM sodium chloride and 20% glycerol.
concentration :
0.99mg/ml
storage stability :
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
app notes :
Suitable for use in ELISA, Western Blot, for biotinylation and iodination.
other info1 :
Grade: Highly Purified
other info2 :
Immunological Functions: 1. Bins IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels including CDC international reference sera).
products categories :
Molecular Biology; MB-Centromeres
products description :
Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENP-A to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies. CENP-B is the most important of the centromeric autoantigens: it has a molecular weight of approx. 66kD and plays an important role in the formation of the centromeric chromatin. CENP-B antibodies are present in the sera of up to 80% of patients with CREST syndrome. Recombinant Human CENP-B produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 80kD.
ncbi gi num :
29863
ncbi acc num :
CAA28918.1
uniprot acc num :
P07199
ncbi mol weight :
80kD
uniprot summary :
CENPB: Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: chromosome; nucleus; chromosome, pericentric region. Molecular Function: centromeric DNA binding; sequence-specific DNA binding; satellite DNA binding; chromatin binding. Biological Process: regulation of transcription, DNA-dependent
size1 :
0.005 mg
price1 :
345 USD
size2 :
0.02 mg
price2 :
420
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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