protein

Hyaluronic Acid Binding Protein 1, Recombinant, Human (Hyaluronan Binding Protein 1, HABP1, C1qBP, C1q-R, Human Complement Component 1, q Subcomponent Binding Protein)

MBS637982

0.1 mg

455 USD

Recombinant Protein

Hyaluronic Acid Binding Protein 1, Recombinant, Human (Hyaluronan Binding Protein 1, HABP1, C1qBP, C1q-R, Human Complement Component 1, q Subcomponent Binding Protein)

Hyaluronic Acid Binding Protein 1

hyaluronan-binding protein 2 isoform 1 preproprotein; Hyaluronan-binding protein 2; hyaluronan-binding protein 2; factor VII activating protein; factor VII-activating protease; factor seven-activating protease; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; plasma hyaluronan-binding protein; hepatocyte growth factor activator-like protein; hyaluronan binding protein 2; Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein

HABP2; HABP2; FSAP; HABP; PHBP; HGFAL; HGFAL; PHBP; FSAP

HABP2_HUMAN

Human, Recombinant, E Coli

MLHTDGDKAF VDFLSDEIKE ERKIQKHKTL PKMSGGWELE LNGTEAKLVR. KVAGEKITVT FNINNSIPPT FDGEEEPSQG QKVEEQEPEL TSTPNFVVEV. IKNDDGKKAL VLDCHYPEDE VGQEDEAESD IFSIREVSFQ STGESEWKDT. NYTLNTDSLD WALYDHLMDF LADRGVDNTF ADELVELSTA LEHQEYITFL. EDLKSFVKSQ

>95% by SDS PAGE

Supplied as a liquid in 20mM Tris, pH 7.5, 1mM DTT, 20% glycerol.

1mg/ml

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA)

Suitable for use in ELISA.

Endotoxin Level: < 1.0EU/1ug protein (LAL method)

Molecular Biology; MB-Carbohydrates, Glycoproteins

Human complement component 1, q subcomponent binding protein (C1QBP) is a ubiquitously expressed multifunctional phospho-protein that interacts with the globular heads of C1q (gC1q). This protein also interacts with a wide range of ligands and is implicated in cell signaling.

4758502

NP_004123.1

NM_004132.3

Q14520

23.9kD (210 aa)

The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between Lys-53 and Lys-54 but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family. Protein type: Secreted; Cell adhesion; Protease; EC 3.4.21.-; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q25.3. Cellular Component: extracellular space; extracellular region. Molecular Function: glycosaminoglycan binding; serine-type endopeptidase activity. Biological Process: cell adhesion; proteolysis. Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5

0.1 mg

455 USD