Sulfotransferase 1A1, Recombinant, Human (SULT1A1, Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, Phenol-sulfating phenol sulfotransferase 1, Phenol sulfotransferase 1, P-PST 1, ST1A3, STP, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotr | MyBioSource MBS637872 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Sulfotransferase 1A1, Recombinant, Human (SULT1A1, Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, Phenol-sulfating phenol sulfotransferase 1, Phenol sulfotransferase 1, P-PST 1, ST1A3, STP, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotr

catalog :

MBS637872

quantity :

0.02 mg

price :

710 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS637872

products type :

Recombinant Protein

products full name :

products short name :

[Sulfotransferase 1A1]

products name syn :

[Sulfotransferase 1A1, Recombinant, Human (SULT1A1, Aryl sulfotransferase 1, HAST1/HAST2, OK/SW-cl.88, Phenol-sulfating phenol sulfotransferase 1, Phenol sulfotransferase 1, P-PST 1, ST1A3, STP, STP1, Sulfotransferase 1A1, Thermostable phenol sulfotransfer]

other names :

[sulfotransferase 1A1 isoform b; Sulfotransferase 1A1; sulfotransferase 1A1; ts-PST; P-PST 1; aryl sulfotransferase 1; thermostable phenol sulfotransferase1; phenol-sulfating phenol sulfotransferase 1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase]

other gene names :

[SULT1A1; SULT1A1; PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2; STP; STP1; ST1A1; P-PST 1; Ts-PST]

uniprot entry name :

ST1A1_HUMAN

host :

E Coli

purity :

Highly Purified. 95% by SDS PAGE under reducing conditions and visualized by silver stain.

form :

Supplied as a liquid in 25mM Tris, pH 7.5, 150mM sodium chloride, 5mM DTT.

concentration :

0.882mg/ml

storage stability :

Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Shipping: Ships with Dry Ice.

tested application :

Western Blot (WB)

app notes :

Optimal dilutions to be determined by the researcher.

other info1 :

N-terminal Sequence Analysis: His. SDS-PAGE: 34kD, reducing conditions. Activity: Measured by its ability to transfer sulfate from PAPS to 1-Napthol. Specific Activity: >30 pmol/min/ug. Endotoxin Level: 1.0 EU per 1ug (LAL).

products categories :

Molecular Biology; MB-Enzymes, Sulfotransferase

products description :

Cytosolic sulfotransferases catalyze the sulfonation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are distinct from Golgi resident sulfotransferases by the absence of transmembrane domains and are located in the cytoplasm. SULT1A1 is one of two phenol sulfotransferases with thermostable enzyme activity. The enzyme is more specific for sulfonation on catecholamines, phenolic drugs and neurotransmitters. Because of its ability to modify diverse promutagen and procarcinogen xenobiotics, it is implicated in a range of cancers. The crystal structure of the enzyme reveals that its active site is flexible and can accommodate diverse hydrophobic substrates with varying sizes, shapes and flexibility.

ncbi gi num :

29540543

ncbi acc num :

NP_803880.1

ncbi gb acc num :

NM_177536.3

uniprot acc num :

P50225

ncbi mol weight :

~34kD

ncbi pathways :

Arylamine Metabolism Pathway (198830); Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Cytosolic Sulfonation Of Small Molecules Pathway (105724); Estrogen Metabolism Pathway (198898); Metabolism Pathway (477135); Phase II Conjugation Pathway (105721); Sulfation Biotransformation Reaction Pathway (198899); Tamoxifen Metabolism Pathway (198804)

ncbi summary :

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SULT1A1: Sulfotransferase that utilizes 3 -phospho-5 -adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.8.2.1; Energy Metabolism - sulfur; Transferase. Chromosomal Location of Human Ortholog: 16p12.1. Cellular Component: cytosol. Molecular Function: sulfotransferase activity; steroid sulfotransferase activity; flavonol 3-sulfotransferase activity; aryl sulfotransferase activity. Biological Process: estrogen metabolic process; flavonoid metabolic process; xenobiotic metabolic process; sulfation; catecholamine metabolic process; amine metabolic process; 3 -phosphoadenosine 5 -phosphosulfate metabolic process

size1 :

0.02 mg

price1 :

710 USD

more info or order :

MyBioSource product webpage