protein

Sulfotransferase 1A3, Cytosolic, Recombinant, Human (SULT1A3)

MBS637653

0.02 mg

710 USD

Recombinant Protein

Sulfotransferase 1A3, Cytosolic, Recombinant, Human (SULT1A3)

[Sulfotransferase 1A3, Cytosolic]

E Coli

95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Supplied as a liquid in 12.5mM Tris, 75mM sodium chloride pH 7.5, 2.5mM DTT, 50% glycerol.

0.922mg/ml

Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB) - Other applications are not tested.

Optimal dilutions to be determined by the researcher.

Host Note: Recombinant enzyme corresponding to Glu2-Leu295 with a N-terminal Met and 6 His tag of human Sulfotransferase 1A3 expressed in E. coli. Endotoxin: 150pmoles/min/ug.

Molecular Biology; MB-Enzymes, Sulfotransferase

Cytosolic sulfotransferases are a family of Phase II drug­metabolizing enzymes that catalyze the sulfation of many endogenous and xenobiotic substrates (1­3). They have important roles in the metabolism of many endogenous compounds including steroids, bile acids, thyroid hormones and monoamine neurotransmitters. They are widely distributed throughout the body and serve to inactivate and increase water­solubility of xenobiotics and therapeutic drugs. They are distinct from Golgi resident sulfotransferases by lacking N­ terminal signal­anchor domains and residing only in the cytoplasm. SULT1A3 catalyzes the sulfation of phenolic monoamines, such as dopamine, norepinephrine and serotonin, and phenolic and catecholic drugs (4, 5). SULT1A3 is also called catecholamine sulfotransferase.

P50224

Predicted Molecular Mass: 35kD; SDS-PAGE: 36kD, reducing conditions

0.02 mg

710 USD