protein

Protein Tyrosine Phosphatase IA2 (693-979), protein tyrosine phosphatase, catalytic domain, Recombinant, Human (PTP-IA2, ICA-512)

MBS636676

0.02 mg

465 USD

Recombinant Protein

Protein Tyrosine Phosphatase IA2 (693-979), protein tyrosine phosphatase, catalytic domain, Recombinant, Human (PTP-IA2, ICA-512)

Protein Tyrosine Phosphatase IA2

PTPRN protein, partial; Receptor-type tyrosine-protein phosphatase-like N; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; protein tyrosine phosphatase, receptor type, N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2

PTPRN; PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; ICA3; ICA512; R-PTP-N; ICA 512

PTPRN_HUMAN

Recombinant, Human from E Coli

Human

>=90%

Supplied as a liquid in 25 Mm Tris-HCl, pH 8.0, 75 mM sodium chloride, 0.05% Tween-20, 2mM EDTA, 1mM DTT, 10mM glutathione, 50% glycerol.

4.72 mg/ml

Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centriuge the original vial after thawing and prior to removing the cap. Shipping: Ships with Dry Ice.

Suitable for the use as an immunogen, in binding assays or as an antigen in autoimmune assays. Other applications not tested. Recommended Dilution: Optimal dilution to be determined by researcher.

Molecular Biology; MB-Enzymes, Phosphatase

Catalytic domain, (a.a. 693-979), MW=32.8kD, expressed in an E. coli expression system.

39644800

AAH07713.2

Q16849

~58.8kD

Type I Diabetes Mellitus Pathway (83095); Type I Diabetes Mellitus Pathway (507)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2q35-q36.1. Cellular Component: integral to membrane. Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity. Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus

0.02 mg

465 USD