protein

ANGPTL4, Recombinant, Mouse (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)

MBS636187

0.01 mg

345 USD

Recombinant Protein

ANGPTL4, Recombinant, Mouse (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)

ANGPTL4

angiopoietin-related protein 4 isoform b; Angiopoietin-related protein 4; angiopoietin-related protein 4; fasting-induced adipose factor; PPARG angiopoietin related protein; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; angiopoietin-like 4; Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein

ANGPTL4; ANGPTL4; NL2; ARP4; FIAF; HARP; PGAR; HFARP; UNQ171; pp1158; ANGPTL2; ARP4; HFARP; PGAR; HFARP

ANGL4_HUMAN

Mouse, COS-7 cells

Mouse ANGPTL4 (aa 1-410) is fused at the C-terminus to a FLAG -tag.

Highly Purified. >90% (SDS-PAGE)

Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.

Short-term Storage: +4 degree C. Long-term Storage: -20 degree C. Working aliquots are stable for up to 3 months when stored at -20 degree C.

Biological Activity: Activates ERK phosphorylation in THP-1 cells.

Molecular Biology; MB-Adipocytes, Adipogenesis

ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.

89264696

NP_001034756.1

NM_001039667.2

Q9BY76

~50kD (SDS-PAGE)

Developmental Biology Pathway (477129); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); Transcriptional Regulation Of White Adipocyte Differentiation Pathway (205243)

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. Protein type: Apoptosis; Inhibitor; Secreted; Extracellular matrix; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: enzyme inhibitor activity; protein binding. Biological Process: positive regulation of angiogenesis; response to hypoxia; negative regulation of lipoprotein lipase activity; angiogenesis; cellular lipid metabolic process; cell differentiation; protein homooligomerization; negative regulation of apoptosis. Disease: Plasma Triglyceride Level Quantitative Trait Locus

0.01 mg

345 USD