product summary
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company name :
MyBioSource
product type :
protein
product name :
APRIL, soluble (H98), Recombinant, Human (ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:)
catalog :
MBS635752
quantity :
0.01 mg
price :
545 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS635752
products type :
Recombinant Protein
products full name :
APRIL, soluble (H98), Recombinant, Human (ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:)
products short name :
[APRIL, soluble]
other names :
[acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic leucine-rich nuclear phosphoprotein 32 family member B; acidic leucine-rich nuclear phosphoprotein 32 family member B; silver-stainable protein SSP29; acidic protein rich in leucines; putative HLA-DR-associated protein I-2; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; Acidic protein rich in leucines; Putative HLA-DR-associated protein I-2; PHAPI2; Silver-stainable protein SSP29]
other gene names :
[ANP32B; ANP32B; APRIL; SSP29; PHAPI2; APRIL; PHAPI2; PHAPI2]
uniprot entry name :
AN32B_HUMAN
host :
Human, HEK 293 cells
sequence :
The extracellular domain of human APRIL (aa 98-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG -tag.
specificity :
Binds to human and mouse BCMA and TACI. Does not bind to proteoglycans.
purity :
Highly Purified. > or = 95% (SDS-PAGE)
form :
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 0.5% trehalose. Reconsititute with 100ul sterile ddH2O.
concentration :
~0.1mg/ml (after reconstitution)
storage stability :
Lyophilized powder may be stored at -20 degree C. Stable for 6 months after receipt at -20 degree C. Reconstitute with sterile ddH2O. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
other info1 :
Biological Activity: Stimulates B cell proliferation. Endotoxin: <0.01EU/ug
products categories :
Molecular Biology; MB-Apoptosis
products description :
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
ncbi gi num :
5454088
ncbi acc num :
NP_006392.1
ncbi gb acc num :
NM_006401.2
uniprot acc num :
Q92688
ncbi mol weight :
~34kD (SDS-PAGE)
uniprot summary :
ANP32B: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. Belongs to the ANP32 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Chaperone. Chromosomal Location of Human Ortholog: 9q22.32. Cellular Component: cytoplasm; nucleolus; nucleus. Molecular Function: histone binding. Biological Process: caspase activation; positive regulation of protein export from nucleus; nucleosome assembly; negative regulation of cell differentiation; vasculature development; ventricular system development; palate development; inner ear development
size1 :
0.01 mg
price1 :
545 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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