catalog number :
MBS635478
products type :
Recombinant Protein
products full name :
IL-38, Recombinant, Human (His) (Interleukin-1 Family Member 10 theta, IL-1F10, FIL1 theta, FKSG75, IL-1HY2, IL1-theta, Interleukin-1 HY2, Interleukin-1 Receptor Antagonist FKSG75)
products short name :
IL-38
other names :
interleukin-1 family member 10; Interleukin-1 family member 10; interleukin-1 family member 10; FIL1 theta; IL-1 theta; interleukin-1 HY2; IL-1F10 (canonical form IL-1F10a); interleukin-1 receptor antagonist FKSG75; interleukin-1 receptor antagonist-like FIL1 theta; interleukin 1 family, member 10 (theta); Family of interleukin 1-theta; FIL1 theta; Interleukin-1 HY2; IL-1HY2; Interleukin-1 theta; IL-1 theta; Interleukin-38
other gene names :
IL1F10; IL1F10; IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta; FIL1T; IL1HY2; IL38; IL-1F10; FIL1 theta; IL-1HY2; IL-1 theta; IL-38
uniprot entry name :
IL1FA_HUMAN
sequence :
Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag.
purity :
Highly Purified. >95% (SDS-PAGE)
form :
Supplied as a lyophilized powder from a 0.2um-filtered solution in 50mM TRIS-Cl, pH 8.2, 150mM NaCl.
storage stability :
Lyohphilized powder may be stored at -20 Deg. Stable for 12 months at -20 Deg. C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 Deg. C. For maximum recovery of product, centrifuge the orignal vial after thawing proir to removing the cap. Further dilutions can be made in assay buffer.
other info1 :
Endotoxin: Specifications: <1EU/ug protein. Reconstitution: Reconstitute with sterile ddH2O
products categories :
Growth Factors, Cytokines; Growth Factors-Interleukin
products description :
IL-38 (IL-1F10) belongs to the IL-1 family. IL-38 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 binds soluble IL-1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.
ncbi acc num :
NP_775184.1
ncbi gb acc num :
NM_173161.2
ncbi mol weight :
~18kD (SDS-PAGE)
ncbi summary :
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
uniprot summary :
IL1F10: Binds soluble IL-1 receptor type 1. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 2q13. Cellular Component: extracellular space. Molecular Function: interleukin-1 receptor binding; cytokine activity. Biological Process: cytokine and chemokine mediated signaling pathway