protein

b2-Microglobulin, Human (B2M)

MBS635141

1 mg

625 USD

Protein

b2-Microglobulin, Human (B2M)

[b2-Microglobulin]

Human urine from patients with renal tubular proteinuria.

>98% (SDS-PAGE)

~1mg/ml (after reconstitution)

Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Suitable for use in ELISA and Western Blot. Other applications have not been tested.

Optimal dilutions to be determined by the researcher.

Form: Supplied as a lyophilized powder in Ammonium bicarbonate. No preservatives added. Reconstitute with 1ml sterile PBS. Care should be taken during reconsitution as the protein may appear as a film at the bottom of the vial. It is recommend that the vial is gently mixed after reconstitution.

Molecular Biology; MB-Serum Proteins

Native beta-2 microglobulin is a component of MHC class I molecules which are present on all nucleated cells. Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients. Also known as B2M, it has been suggested that protein can be used as a prognostic marker for HIV infection.

12kD

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; plasma membrane; MHC class I protein complex. Molecular Function: protein homodimerization activity; peptide antigen binding; receptor binding. Biological Process: immune response-inhibiting cell surface receptor signaling pathway; regulation of immune response; positive regulation of regulatory T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tolerance induction; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of T cell proliferation; cellular defense response; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of T cell tolerance induction. Disease: Asthma, Susceptibility To

1 mg

625 USD