Follicle Stimulating Hormone Receptor, Human (FSH Receptor, FSHr, FSH-R, FSHRO, Follitropin Receptor, LGR1, MGC141667, MGC141668, ODG1) | MyBioSource MBS634976 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Follicle Stimulating Hormone Receptor, Human (FSH Receptor, FSHr, FSH-R, FSHRO, Follitropin Receptor, LGR1, MGC141667, MGC141668, ODG1)

catalog :

MBS634976

quantity :

0.05 mg

price :

340 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS634976

products type :

Protein

products full name :

Follicle Stimulating Hormone Receptor, Human (FSH Receptor, FSHr, FSH-R, FSHRO, Follitropin Receptor, LGR1, MGC141667, MGC141668, ODG1)

products short name :

Follicle Stimulating Hormone Receptor

other names :

follicle stimulating hormone receptor; Follicle-stimulating hormone receptor; follicle-stimulating hormone receptor; FSH receptor; follitropin receptor; follicle stimulating hormone receptor; Follitropin receptor

other gene names :

FSHR; FSHR; LGR1; ODG1; FSHRO; LGR1; FSH-R

uniprot entry name :

FSHR_HUMAN

host :

Synthetic peptide corresponding to AIELRFVLTKLRVI of synthetic human FSH receptor.

purity :

Purified. >80% (HPLC)

form :

Supplied as a lyophilized powder. Reconstitute with ddH2O.

storage stability :

Lyophilized powder may be store at -20 degree C. Stable for 6 months after receipt at -20 degree C. Reconstitute with sterile, ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the orignal vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA)

app notes :

Suitable for use in ELISA. Other appications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher.

products categories :

Molecular Biology; MB-Receptors

ncbi gi num :

300073

ncbi acc num :

AAB26480.1

uniprot acc num :

P23945

ncbi mol weight :

78,265 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); FSH Signaling Pathway (672455); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Hormone Ligand-binding Receptors Pathway (106369); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

uniprot summary :

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 2p21-p16. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; follicle-stimulating hormone receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; gonad development; follicle-stimulating hormone signaling pathway; male gonad development; female gamete generation; spermatogenesis; female gonad development. Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

size1 :

0.05 mg

price1 :

340 USD

more info or order :

MyBioSource product webpage