protein

Vitamin D Binding Protein (VDBP, VDB, DBP, DBP/GC, Gc Globulin, Group Specific Component, Group-specific Component, GC, hDBP, Vitamin D Binding alpha Globulin, VDBG)

MBS634934

1 mg

400 USD

Protein

Vitamin D Binding Protein (VDBP, VDB, DBP, DBP/GC, Gc Globulin, Group Specific Component, Group-specific Component, GC, hDBP, Vitamin D Binding alpha Globulin, VDBG)

Vitamin D Binding Protein

vitamin D-binding protein isoform 3; Vitamin D-binding protein; vitamin D-binding protein; VDB; gc-globulin; vitamin D-binding alpha-globulin; group-specific component (vitamin D binding protein); Gc-globulin; Group-specific component

GC; GC; DBP; GRD3; VDBG; VDBP; DBP/GC; DBP; VDB

VTDB_HUMAN

Human plasma

Purified. >95% by SDS-PAGE

Supplied as a lyophilized powder from 20mM sodium phosphate, 150mM sodium chloride, pH 7.4. Reconstitute with 266ul sterile ddH2O.

~3.76mg/ml (After reconstitution)

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with 435ul sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to emoving the cap. Further dilutions can be made in assay buffer.

Molecular Biology; MB-Binding Proteins

The vitamin D binding protein (DBP) is a multifunctional plasma protein that can modulate certain immune and inflammatory responses. The diverse cellular functions of DBP appear to require cell surface binding to mediate these processes. Numerous reports have detected DBP bound to the surface of several cell types and would support the concept of a cell surface binding site for DBP.

324021745

NP_001191236.1

NM_001204307.1

P02774

52kD

Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150); Vitamin D (calciferol) Metabolism Pathway (160956); Vitamin D Synthesis Pathway (198764)

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q12-q13. Cellular Component: lysosomal lumen; extracellular space; extracellular region; cytosol. Molecular Function: vitamin D binding; actin binding; vitamin transporter activity. Biological Process: steroid metabolic process; vitamin transport; vitamin D metabolic process. Disease: Graves Disease, Susceptibility To, 1

1 mg

400 USD