Plasmin, Bovine | MyBioSource MBS634887 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Plasmin, Bovine

catalog :

MBS634887

quantity :

1 mg

price :

675 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS634887

products type :

Protein

products full name :

Plasmin, Bovine

products short name :

[Plasmin, Bovine]

other names :

[plasminogen isoform 1; Plasminogen; plasminogen; plasminogen]

other gene names :

[PLG; PLG]

uniprot entry name :

PLMN_HUMAN

purity :

Purified. Lysine Sepharose Chromatography

form :

Supplied as a liquid in 0.1M HEPES, 0.1M sodium chloride, pH 7.4.

concentration :

As reported.

storage stability :

Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Ships with dry ice.

other info1 :

Source: Bovine Plasmin. Activity: The preparation as provided exhibits 100% theoretical activity with a greater than >95% actual activity.

products categories :

Molecular Biology; MB-Coagulation Factors

products description :

Bovine plasmin is prepared from isolated plasminogen via activation with immobilized uPA.

ncbi gi num :

4505881

ncbi acc num :

NP_000292.1

ncbi gb acc num :

NM_000301.3

uniprot acc num :

P00747

ncbi mol weight :

83kD

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (576264); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Dissolution Of Fibrin Clot Pathway (106061); Extracellular Matrix Organization Pathway (576262); Hemostasis Pathway (106028)

ncbi summary :

The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

uniprot summary :

Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Defects in PLG are the cause of plasminogen deficiency (PLGD). PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Belongs to the peptidase S1 family. Plasminogen subfamily. Protein type: Protease; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.21.7. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: extracellular space; cell surface; extrinsic to external side of plasma membrane; plasma membrane; extracellular region. Molecular Function: protein domain specific binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; apolipoprotein binding; receptor binding. Biological Process: platelet activation; extracellular matrix organization and biogenesis; tissue remodeling; myoblast differentiation; muscle maintenance; extracellular matrix disassembly; negative regulation of cell proliferation; fibrinolysis; cellular protein metabolic process; platelet degranulation; negative regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; tissue regeneration; positive regulation of fibrinolysis; blood coagulation; transmembrane transport. Disease: Plasminogen Deficiency, Type I

size1 :

1 mg

price1 :

675 USD

more info or order :

MyBioSource product webpage