Vanilloid Receptor 1 (Capsaicin rRceptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV1, Vanilloid receptor subtype 1, VR1) | MyBioSource MBS634821 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Vanilloid Receptor 1 (Capsaicin rRceptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV1, Vanilloid receptor subtype 1, VR1)

catalog :

MBS634821

quantity :

1 mg

price :

300 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS634821

products type :

Protein

products full name :

Vanilloid Receptor 1 (Capsaicin rRceptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV1, Vanilloid receptor subtype 1, VR1)

products short name :

Vanilloid Receptor 1

other names :

vanilloid receptor 1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; transient receptor potential cation channel, subfamily V, member 1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1

other gene names :

TRPV1; TRPV1; VR1; VR1; TrpV1; OTRPC1

uniprot entry name :

TRPV1_HUMAN

host :

Synthetic peptide

reactivity :

Mouse

sequence :

H-Cys-Glu-Asp-Ala-Glu-Val-Phe-Lys-Asp-Ser-Met-Ala-Pro-Gly-Glu-Lys-OH

purity :

~95%. Purified by HPLC

form :

Supplied as a lyophilized powder

storage stability :

Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

Immunohistochemistry (IHC)

app notes :

Suitable for use in Immunohistochemistry., Control Peptide is 22aa CEDAEVFKDSMAPGEK (linear) from the C-terminus of mouse Vanilloid Receptor 1. See corresponding antibody C1078-02.

other info1 :

Molecular Formula: C 73 H 11 N 18 O 28 S 2

products categories :

Molecular Biology; MB-Ion Channel

products description :

VR1 (vanilloid receptor 1) is an ion channel activated by capsaicin, the pungent ingredient in hot peppers, and by noxious thermal heat. It is expressed by and isolated from nociceptive sensory neurons. Sequence analysis suggests that VR1 has transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. It is thought to function as a transducer of noxious thermal stimuli and have involvement in inflammatory pain.

ncbi gi num :

15028819

ncbi acc num :

CAB89866.2

uniprot acc num :

Q8NER1

ncbi mol weight :

1754.95

ncbi pathways :

Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Trk Receptor Signaling Mediated By PI3K And PLC-gamma Pathway (137967); Trk Receptor Signaling Mediated By The MAPK Pathway (138044)

ncbi summary :

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TRPV1: a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Receptor, misc. Chromosomal Location of Human Ortholog: 17p13.2. Cellular Component: postsynaptic membrane; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; intrinsic to plasma membrane. Molecular Function: calmodulin binding; transmembrane receptor activity; excitatory extracellular ligand-gated ion channel activity; calcium-release channel activity; calcium channel activity; phosphoprotein binding; ATP binding. Biological Process: cell surface receptor linked signal transduction; transport; chemosensory behavior; thermoception; transmembrane transport

size1 :

1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage