Transferrin, Bovine, Iron Saturated (HOLO), USA Origin | MyBioSource MBS634766 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Transferrin, Bovine, Iron Saturated (HOLO), USA Origin

catalog :

MBS634766

quantity :

250 mg

price :

245 USD

more info or order :

MyBioSource product webpage

image

image 1 :

Transferin, TF, Apotransferrin, Beta-1 Metal-binding Globulin, DKFZp781D0156, PRO1400, PRO1557, PRO2086, Serotransferrin Precursor, Siderophilin

product information

catalog number :

MBS634766

products type :

Protein

products full name :

Transferrin, Bovine, Iron Saturated (HOLO), USA Origin

products short name :

[Transferrin, Bovine, Iron Saturated]

other names :

[transferrin; Serotransferrin; serotransferrin; siderophilin; beta-1 metal-binding globulin; transferrin; Beta-1 metal-binding globulin; Siderophilin]

other gene names :

[TF; TF; TFQTL1; PRO1557; PRO2086; Transferrin]

uniprot entry name :

TRFE_HUMAN

purity :

Molecular Biology Grade. Purity: 100%

storage stability :

4 degree C

image1 heading :

Testing Data

other info1 :

CAS Number: 11096-37-0. Country of Origin: USA. Appearance: Reddish powder. Iron: 1403ug/g. Moisture (KF): 3.8. Protein: 100%. Moisture (KF): 3.8%. Sodium: 3.5 mg/g. Chloride: 0.5mg/g. pH (3%): 7.81 . Ash: 2.4%. Endotoxin: <0.1EU/mg. Working Concentration: 5-10ug/ml. Virus: Virus P13: Absent. fBR: Absent. BVO: Absent. Mycoplasma: Absent. BfuetonQue: Absent. Bovine Adenoviruses: Absent. Bovine Respiratory syncytial virus: Absent. Robles: Absent. Reovirus: Absent. Bovine Parvovirus: Absent

other info2 :

Certificate of Origin: All raw material used in the manufacturing of Transferrin is of US origin and was manufactured in USDA-registered plants. The animals used receiveCl both ante- and post-mortem inspections under certified veterinary care and were inspected to be free of apparent infectious and contagious diseases infections and injurious parasites known to be transferable to hoofed animals, such as blue-tongue fever. In addition, all materials were heated during processing to a temperature exceeding (65 degree C) for a period of 10 hours and subjected to a pH of 5.0 or lower for at least 3 hours. Foot and mouth disease, rinderpest, contagious bovine pleur0p.neumonia, hog cholera, swine vesticular disease and African swine fever are not known to exist in the United States. Age of bovine raw material is less than 3 year.

products categories :

Molecular Biology; MB-Transferrin

products description :

Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 79.5kD and a serum concentration range of 1800-2700mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. Isolated from fresh bovine plasma from certified USA herds and tested for adventitious viruses, bovine transferrin is an essential cellular transport protein via receptor-mediated endocytosis. Suitable for use in serum-free media and RPMI.

ncbi gi num :

339453

ncbi acc num :

AAA61140.1

uniprot acc num :

P02787

ncbi mol weight :

76-81kD

ncbi pathways :

EPHB Forward Signaling Pathway (138047); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (187191); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

uniprot summary :

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q22.1. Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle. Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding. Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport. Disease: Atransferrinemia

size1 :

250 mg

price1 :

245 USD

size2 :

1 g

price2 :

365

size3 :

10 g

price3 :

2800

more info or order :

MyBioSource product webpage