protein

Fibrinogen, Human (Fibrinogen A alpha Polypeptide, Fibrinogen alpha Chain, FGA, Fibrinogen B alpha Polypeptide, Fibrinogen beta Chain, FGB, Fibrinogen G alpha Polypeptide, Fibrinogen gamma Chain, FGG, Fib2, MGC104327, MGC119422, MGC119423, MGC119425

MBS634624

25 mg

445 USD

Protein

Fibrinogen, Human (Fibrinogen A alpha Polypeptide, Fibrinogen alpha Chain, FGA, Fibrinogen B alpha Polypeptide, Fibrinogen beta Chain, FGB, Fibrinogen G alpha Polypeptide, Fibrinogen gamma Chain, FGG, Fib2, MGC104327, MGC119422, MGC119423, MGC119425, MGC1

[Fibrinogen]

[Fibrinogen, Human (Fibrinogen A alpha Polypeptide, Fibrinogen alpha Chain, FGA, Fibrinogen B alpha Polypeptide, Fibrinogen beta Chain, FGB, Fibrinogen G alpha Polypeptide, Fibrinogen gamma Chain, FGG, Fib2, MGC104327, MGC119422, MGC119423, MGC119425, MGC1]

[fibrinogen; Fibrinogen gamma-B chain; fibrinogen gamma-B chain; gamma'; fibrinogen, gamma polypeptide; fibrinogen gamma chain<]

[FGG; FGG; Gamma']

FIBG_BOVIN

Human Fibrinogen from human plasma

Purified by precipitation

Supplied as a liquid in citrate buffered saline. No preservative added.

1.25mg/ml

May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Functional Assays. Other applications not tested.

Optimal dilutions to be determined by the researcher.

Source note: Human Fibrinogen from human plasma. 35-65% protein, of which >=90% clottable protein. Virtually free from plasminogen and plasmin.

Molecular Biology; MB-Coagulation Factors

350

CAA33562.1

P12799

340kD

Common Pathway (827720); Complement And Coagulation Cascades Pathway (84312); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (827717); GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway (827019); Hemostasis Pathway (827694); Integrin AlphaIIb Beta3 Signaling Pathway (827018); Integrin Cell Surface Interactions Pathway (827017); Platelet Aggregation (Plug Formation) Pathway (827712); Platelet Activation, Signaling And Aggregation Pathway (827704)

Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain . By similarity. Subcellular location: Secreted. Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure. Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sequence similarities: Contains 1 fibrinogen C-terminal domain.

25 mg

445 USD