Folate Binding Protein, Bovine | MyBioSource MBS634513 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Folate Binding Protein, Bovine

catalog :

MBS634513

quantity :

1 mg

price :

745 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS634513

products type :

Protein

products full name :

Folate Binding Protein, Bovine

products short name :

Folate Binding Protein, Bovine

other names :

folate receptor alpha; Folate receptor alpha; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18; folate receptor 1 (adult); Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18

other gene names :

FOLR1; FOLR1; FBP; FOLR; FOLR; FR-alpha; FBP

uniprot entry name :

FOLR1_HUMAN

purity :

Purified. 95% (HPLC)

form :

Supplied as a liquid in PBS, pH 7.4. No preservative added.

storage stability :

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA)

app notes :

Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher.

other info2 :

Protein Content: 2.3mg/ml (indirectly using the measured activity in ug/ml and the binding capacity of 8ug folic acid/mg folate binding protein.). Activity: 18.6ug/ml (Folate binding)

products categories :

Molecular Biology; MB-Serum Proteins

products description :

Folate Binding Protein, has a high affinity for folic acid and for several reduced folic acid derivatives and mediates delivery of 5 methyltetrahydrofolate to the interior of cells. Membrane bound and soluble forms of a high affinity folate binding protein have been found in kidney, placenta, serum, milk, and in several cell lines. The 2 forms have similar binding characteristics for folates, are immunologically crossreactive, and, based upon limited amino acid sequence data, are nearly identical. There may be a precursor product relationship between the membrane and soluble forms, the membrane form having additional amino acid residues and greater molecular weight. The membrane form has been shown to mediate the transport of folate in cells grown in physiologic concentrations of folate. A function for the soluble form, which is found in serum, milk, and urine, has not been identified.

ncbi gi num :

9257213

ncbi acc num :

NP_057941.1

ncbi gb acc num :

NM_016729.2

uniprot acc num :

P15328

ncbi mol weight :

29,819 Da

ncbi pathways :

Endocytosis Pathway (102279); Endocytosis Pathway (102181)

ncbi summary :

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

uniprot summary :

FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 11q13.3-q14.1. Cellular Component: anchored to external side of plasma membrane; cell surface; clathrin-coated vesicle; membrane; integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; endosome. Molecular Function: folic acid transporter activity; receptor activity; folic acid binding. Biological Process: receptor-mediated endocytosis; folic acid metabolic process; folic acid transport. Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency

size1 :

1 mg

price1 :

745 USD

more info or order :

MyBioSource product webpage