protein

Collagen Type V, Bovine

MBS634348

0.5 mg

555 USD

Protein

Collagen Type V, Bovine

Collagen Type V, Bovine

collagen type V alpha-2, partial; Collagen alpha-2(V) chain; collagen alpha-2(V) chain; collagen alpha-2(V) chain; AB collagen; type V preprocollagen alpha 2 chain; collagen, fetal membrane, A polypeptide; collagen, type V, alpha 2

COL5A2; COL5A2

CO5A2_HUMAN

Recognizes anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% crossreactivity was detected by ELISA).

Highly Purified. Purified by ion exchange chromatography. IEP Assay shows a single precipitin arc against source serum protein and IgG.

Supplied as a lyophilized powder in PBS, pH 7.2. No preservative added. No stabilizing proteins added.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C or colder. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

Suitable for use as a control or standard in ELISA, Western Blotting, Immunoprecipitation.

Molecular Biology; MB-Collagen

179698

AAA51859.1

P05997

144,910 Da

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]

COL5A2: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A2 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q14-q32. Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region. Molecular Function: metal ion binding; extracellular matrix structural constituent; SMAD binding. Biological Process: skin development; extracellular matrix disassembly; axon guidance; collagen catabolic process; extracellular matrix organization and biogenesis; ossification; collagen fibril organization; skeletal development; eye morphogenesis. Disease: Ehlers-danlos Syndrome, Type I

0.5 mg

555 USD