protein

a-Fetoprotein, Human (AFP, Alpha1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP)

MBS634297

0.002 mg

395 USD

Protein

a-Fetoprotein, Human (AFP, Alpha1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP)

a-Fetoprotein

alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; FETA; HPAFP; HPAFP

FETA_HUMAN

Human cord serum

Purified. Purified

Supplied as a liquid in 0.1M PBS, pH 7.4, 0.1% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA, Western Blot and Inhibition assays.

Molecular Biology; MB-Serum Proteins

AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.

4501989

NP_001125.1

NM_001134.2

P02771

70kD

Direct P53 Effectors Pathway 137939!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!Hippo Signaling Pathway 749777!!Hippo Signaling Pathway 750388

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form. Subcellular location: Secreted. Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac. Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma. Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated. Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

0.002 mg

395 USD