protein

Wnt4 (Wnt4, Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member 4, Wnt-4, Wnt-4 Protein Precursor) (Control Peptide)

MBS633994

0.1 mg

350 USD

Peptide

Wnt4 (Wnt4, Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member 4, Wnt-4, Wnt-4 Protein Precursor) (Control Peptide)

Wnt4

WNT4; Protein Wnt-4; protein Wnt-4; wingless-type MMTV integration site family, member 4

WNT4; WNT4; WNT-4; SERKAL

WNT4_HUMAN

Synthetic

C-SNWLYAKLSSVGS

Recognizes Human, Mouse, Rat Wnt4

Purified

Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile ddH2O.

~0.5mg/ml

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA) and Antibody Blocking. Other applications not tested.

Recommended Dilutions: . Antibody Blocking: 1:1 1ug antibody/1peptide. Optimal dilutions to be determined by the researcher.

Molecular Biology; MB-Wnt Proteins

C-SNWLYLAKLSSVGS, internal region

13430197

AAK25765.1

P56705

39,052 Da

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Class B/2 (Secretin Family Receptors) Pathway (106378); DNA Damage Response (only ATM Dependent) Pathway (198827); GPCR Ligand Binding Pathway (161020); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hedgehog Signaling Pathway (83063); Hedgehog Signaling Pathway (474); Hippo Signaling Pathway (749777)

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5 000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.23-p35.1. Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen; Golgi lumen; cytoplasm; extracellular region; plasma membrane. Molecular Function: frizzled binding; transcription corepressor activity; receptor agonist activity. Biological Process: negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; thyroid stimulating hormone secreting cell differentiation; Wnt receptor signaling pathway through beta-catenin; androgen biosynthetic process; somatotropin secreting cell differentiation; neuron differentiation; regulation of cell-cell adhesion; positive regulation of focal adhesion formation; positive regulation of aldosterone biosynthetic process; positive regulation of stress fiber formation; embryonic epithelial tube formation; kidney development; negative regulation of cell migration; female gonad development; cell fate commitment; positive regulation of meiosis; adrenal gland development; male gonad development; immature T cell proliferation in the thymus; cellular response to starvation; positive regulation of bone mineralization; liver development; positive regulation of osteoblast differentiation; negative regulation of cell differentiation; protein palmitoylation; ureteric bud branching; epithelial to mesenchymal transition; female sex determination; smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; oocyte development. Disease: Mullerian Aplasia And Hyperandrogenism; 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs

0.1 mg

350 USD