catalog number :
MBS633906
products full name :
Somatostatin 14 [D-Trp8]
products short name :
Somatostatin 14 [D-Trp8]
other names :
somatostatin preproprotein; Somatostatin; somatostatin; somatostatin-14; somatostatin-28; prepro-somatostatin; growth hormone release-inhibiting factor; somatostatin; Growth hormone release-inhibiting factor
other gene names :
SST; SST; SMST
uniprot entry name :
SMS_HUMAN
sequence :
Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)
purity :
Highly Purified. ~95%. Purified by HPLC.
form :
Supplied as a lyophilized powder
storage stability :
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
products categories :
Molecular Biology; MB-Peptides
ncbi acc num :
NP_001039.1
ncbi gb acc num :
NM_001048.3
ncbi mol weight :
12,736 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Peptide Ligand-binding Receptors Pathway (106358); SIDS Susceptibility Pathways (198901); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
uniprot summary :
SST: Somatostatin inhibits the release of somatotropin. Belongs to the somatostatin family. Protein type: Secreted, signal peptide; Secreted; Hormone. Chromosomal Location of Human Ortholog: 3q28. Cellular Component: extracellular space; cell soma; extracellular region. Molecular Function: hormone activity. Biological Process: response to drug; induction of apoptosis by hormones; response to amino acid stimulus; regulation of cell migration; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; synaptic transmission; hyperosmotic response; cell surface receptor linked signal transduction; cell-cell signaling; response to steroid hormone stimulus; response to heat; digestion; response to nutrient