Adrenomedullin (13-52) (human) | MyBioSource MBS633873 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Adrenomedullin (13-52) (human)

catalog :

MBS633873

quantity :

1 mg

price :

645 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS633873

products type :

Peptide

products full name :

Adrenomedullin (13-52) (human)

products short name :

[Adrenomedullin]

other names :

[adrenomedullin; ADM; ADM; preproadrenomedullin; adrenomedullin; ProAM N-terminal 20 peptide]

other gene names :

[ADM; ADM; AM; AM; AM; PAMP; ProAM-N20]

uniprot entry name :

ADML_HUMAN

reactivity :

Human

sequence :

Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

purity :

95.31%. Highly Purified

form :

Supplied as a lyophilized powder

storage stability :

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. Reconsituted product is stable for 12 months at -20 dgree C.

other info1 :

Source: Synthetic peptide. Molecular Formula: C 200 H 310 N 58 O 59 S 2 . Appearance: White to off-white powder.

products categories :

Molecular Biology; MB-Peptides

ncbi gi num :

765330

ncbi acc num :

AAC60642.1

uniprot acc num :

P35318

ncbi mol weight :

4535.17

ncbi pathways :

Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); HIF-1-alpha Transcription Factor Network Pathway (138045); Myometrial Relaxation And Contraction Pathways (198759); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

ncbi summary :

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]

uniprot summary :

ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p15.4. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: protein binding; adrenomedullin receptor binding; hormone activity; receptor binding. Biological Process: developmental growth; positive regulation of apoptosis; blood circulation; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; positive regulation of vasodilation; signal transduction; response to insulin stimulus; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; cell-cell signaling; receptor internalization; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; response to wounding; vasculogenesis; regulation of the force of heart contraction; aging; hormone secretion; organ regeneration; progesterone biosynthetic process; androgen metabolic process; neurite regeneration; positive regulation of heart rate; negative regulation of vasoconstriction; odontogenesis of dentine-containing teeth; response to starvation; positive regulation of angiogenesis; G-protein coupled receptor internalization; neural tube closure; negative regulation of vascular permeability; response to hypoxia; cAMP biosynthetic process; response to cold

size1 :

1 mg

price1 :

645 USD

more info or order :

MyBioSource product webpage