antibody

Phosphatase, Alkaline, Bone (BALP, BAP, Alkaline Phosphatase Liver/bone/kidney, ALPL, AKP2, Alkaline Phosphatase Tissue Nonspecific Isozyme, Alkaline Phosphomonoesterase, AP-TNAP, FLJ40094, Glycerophosphatase, HOPS, Liver/bone/kidney Isozyme, PHOA,

MBS632877

0.2 mg

640 USD

monoclonal

mouse

AP

[10B141]

western blot, ELISA, enzyme immunoassay

Antibody

Phosphatase, Alkaline, Bone (BALP, BAP, Alkaline Phosphatase Liver/bone/kidney, ALPL, AKP2, Alkaline Phosphatase Tissue Nonspecific Isozyme, Alkaline Phosphomonoesterase, AP-TNAP, FLJ40094, Glycerophosphatase, HOPS, Liver/bone/kidney Isozyme, PHOA, Tissue

[Phosphatase, Alkaline, Bone]

[Anti -Phosphatase, Alkaline, Bone (BALP, BAP, Alkaline Phosphatase Liver/bone/kidney, ALPL, AKP2, Alkaline Phosphatase Tissue Nonspecific Isozyme, Alkaline Phosphomonoesterase, AP-TNAP, FLJ40094, Glycerophosphatase, HOPS, Liver/bone/kidney Isozyme, PHOA, Tissue]

Monoclonal

IgG1

[10B141]

Mouse

Human

Recognizes human alkaline phosphatase, a hydrolase enzyme most active at alkaline pH. Detects the tissue isotypes BAP, PLAP, and IAP (bone, placental and intestinal alkaline phosphatase), but may react with other alkaline phosphatases.

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

1mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot. Dilution:. Western Blot: Detects a band at ~70kD. Immunohistochemistry (IHC): Paraffin sections. Optimal dilutions to be determined by the researcher.

Immunogen: Alkaline phosphatase from human bone

Grade: Affinity Purified

Antibodies; Abs to Enzymes, Phosphatase

Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). Although the exact biochemical function of BAP is uncertain, measurement of the serum levels of BAP can be used as a biochemical indicator of bone turnover. Conditions which present with a decrease in the level of BAP (hypophosphatasemia) include the inherited bone-deforming disorder hypophosphatasia and osteoporosis, while an increase in BAP (hyperphosphatasemia) is associated with Paget's disease, bone fractures and osteosarcomas.

0.2 mg

640 USD