antibody

HIV-1 gp120, Strain IIIB (Human Immunodeficiency Virus Type 1) (FITC)

MBS632531

50 Tests

580 USD

monoclonal

mouse

FITC

5i20

Antibody

HIV-1 gp120, Strain IIIB (Human Immunodeficiency Virus Type 1) (FITC)

HIV-1 gp120, Strain IIIB

Anti -HIV-1 gp120, Strain IIIB (Human Immunodeficiency Virus Type 1) (FITC)

Monoclonal

IgG

5i20

Mouse

Recognizes native and recombinant HIV-1 gp120.

> = 95% Purified by gel exclusion chromatography.

Supplied as a liquid in 10mM Tris, pH 8.0. No stabilizers or preservatives added. Labeled with fluorescein isothiocyanate (FITC).

1mg/ml

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.

Dot Blot (DB), FACS, Immunohistochemistry (IHC) and Direct Immunofluorescence. Other applications not tested.

Suitable for use in Dot Blot, FACS, Immunohistochemistry and Direct Immunofluorescence. Dilution: Direct Immunofluorescence: 1:50. Dot Blot: 1:200

Immunogen: HIV-1 gp120

Grage: Highly Purified. Note: This product is Light Sensitive. F/P Ratio: 3-4

Antibodies; Abs to Infectious Disease HIV

HIV is a member of the genus Lentivirus, part of the family of Retroviridae, which use reverse transcriptase to convert the viral RNA genome into double stranded DNA. This is then integrated into the cell's DNA, which is followed by latency or active HIV replication. HIV primarily infects CD4+ T lymphocytes, resulting in their dramatic decline. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. If untreated, this can lead to AIDS (Acquired Immunodeficiency Syndrome). Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

50 Tests

580 USD