antibody

Mannose 6 Phosphate Receptor, Cation-independent (Cation-independent Mannose-6-phosphate Receptor, CI Man-6-P Receptor, CI-MPR, M6PR, 300kD Mannose 6-phosphate Receptor, MPR 300, Insulin-like Growth Factor 2 Receptor, Insulin-like Growth Factor II R

MBS632483

0.5 mg

810 USD

monoclonal

mouse

nonconjugated

[10K74]

ELISA, enzyme immunoassay

Antibody

Mannose 6 Phosphate Receptor, Cation-independent (Cation-independent Mannose-6-phosphate Receptor, CI Man-6-P Receptor, CI-MPR, M6PR, 300kD Mannose 6-phosphate Receptor, MPR 300, Insulin-like Growth Factor 2 Receptor, Insulin-like Growth Factor II Recepto

[Mannose 6 Phosphate Receptor, Cation-independent]

[Anti -Mannose 6 Phosphate Receptor, Cation-independent (Cation-independent Mannose-6-phosphate Receptor, CI Man-6-P Receptor, CI-MPR, M6PR, 300kD Mannose 6-phosphate Receptor, MPR 300, Insulin-like Growth Factor 2 Receptor, Insulin-like Growth Factor II Recepto]

[mannose 6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; insulin-like growth factor 2 receptor; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor]

[IGF2R; IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R; MPRI]

MPRI_HUMAN

Monoclonal

IgG2B

[10K74]

Mouse

Human

Recognizes human IGF-II R.

Purified by Protein G affinity chromatography from hybridoma culture supernatant.

Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 1ml sterile PBS.

~0.5mg/ml (after reconstitution)

Lyophilized and reconstituted products are stable for 12 months after receipt at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

ELISA (EL/EIA)

Suitable for use in ELISA. Dilution: ELISA (capture): 2-8ug/ml. Optimal dilutions to be determined by the researcher.

Immunogen: Recombinant protein corresponding to ser1510-Phe2108 of human IGF-II R, expressed in NSO cells. Species Sequence Homology: mouse and bocine 85%.

Hybridoma: Fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, NS0-derived, recombinant human IGF-II R.

Antibodies; Abs to Golgi Proteins

Insulin-like Growth Factor 2 receptor (IGF-II R), also known as cation-independent mannose-6 phosphate receptor (CI-MPR), is a 300kD, 2264aa type I transmembrane glycoprotein of the P-type lectin family. The extracellular region contains 15 repeats that mediate homodimer formation and multifunctional binding of IGF-II and many other proteins that do and do not contain mannose-6 phosphates. IGF-II R generally regulates endocytosis and lysosomal/endosomal trafficking. Human IGF-II R shares 85% aa identity with mouse and cow IGF-II R within the extracellular region used as an immunogen.

188672

P11717

274,375 Da

Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Lysosome Pathway (99052); Lysosome Pathway (96865); Membrane Trafficking Pathway (106160); Trans-Golgi Network Vesicle Budding Pathway (106165)

The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq]

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Protein type: Membrane protein, integral; Vesicle; Receptor, misc. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: extracellular space; cell surface; focal adhesion; clathrin coat; integral to plasma membrane; lysosomal membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; endocytic vesicle; late endosome; endosome. Molecular Function: G-protein coupled receptor activity; mannose binding; identical protein binding; protein binding; retinoic acid binding; enzyme binding; transporter activity; phosphoprotein binding; G-protein alpha-subunit binding; receptor activity; glycoprotein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development. Disease: Hepatocellular Carcinoma

0.5 mg

810 USD