product summary
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company name :
MyBioSource
product type :
antibody
product name :
Tetanus Toxin, Clostridium tetani (Tetanospasmin, TeNT)
catalog :
MBS632310
quantity :
1 mg
price :
545 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9B138
application :
western blot, ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS632310
products type :
Antibody
products full name :
Tetanus Toxin, Clostridium tetani (Tetanospasmin, TeNT)
products short name :
Tetanus Toxin, Clostridium tetani
products name syn :
Anti -Tetanus Toxin, Clostridium tetani (Tetanospasmin, TeNT)
other names :
tetanus toxin
clonality :
Monoclonal
isotype :
IgG1
clone :
9B138
host :
Mouse
specificity :
Recognizes the tetanus toxin. Has toxin neutralization activity (in vivo assay).
purity :
Affinity Purified. Purified by Protein G chromatography.
form :
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
concentration :
10.7 mg/ml
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Western Blot (WB)
app notes :
Suitable for use in ELISA and Western Blot.
other info1 :
Immunogen: Supernatant from C. tetani.
other info2 :
Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice.
products categories :
Antibodies; Abs to Infectious Disease
products description :
Tetanus toxin is polypeptide composed of two chains [A chain (55kD) and B chain (105kD)]. The toxin is carried to CNS via bloodstream. Tetanus toxin binds at neuromuscular synapses via ganglioside receptors (sialic acid) via B-chain. The toxin is then internalized via receptor-mediated endocytosis. The A chain is thought to be the toxic subunit by analogy to diptheria and cholera toxin. It has no known effect on any cellular enzyme systems. The action of the holotoxin (A + B chains) is to interfere with synaptic transmission by preferentially inhibiting the release of inhibitory neurotransmitters such as glycine and GABA from inhibitory neurons. This inhibition causes rigid muscle contraction-spastic paralysis. Tetanus toxin is an exotoxin. These toxins are secreted by a bacterial cell into surrounding fluids. Exotoxins are produced by both Gram-negative and Gram-positive bacteria. Most exotoxins are readily destroyed by heat. They can be converted into toxoids that are used as vaccines. Exotoxins are extrememly powerful biological poisons as in the case of tetanus. It has been estimated that 1mg of purified tetanus toxin could kill millions of mice.
ncbi gi num :
144921
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)
size1 :
1 mg
price1 :
545 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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