MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, | MyBioSource MBS632159 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757,

catalog :

MBS632159

quantity :

1 mL

price :

605 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M3II-9

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS632159

products type :

Antibody

products full name :

products short name :

MRP3

products name syn :

Anti -MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, MLP2

other names :

MRP3; Canalicular multispecific organic anion transporter 2; canalicular multispecific organic anion transporter 2; OTTHUMP00000221667; OTTHUMP00000221668; OTTHUMP00000221670; multidrug resistance associated protein; multidrug resistance-associated protein 3; ATP-binding cassette sub-family C member 3; multi-specific organic anion transporter D; canicular multispecific organic anion transporter; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3

other gene names :

ABCC3; ABCC3; MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757; DKFZp686E22157; CMOAT2; MLP2; MRP3

uniprot entry name :

MRP3_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

M3II-9

host :

Mouse

reactivity :

Human

specificity :

Recognizes an internal epitope of MRP3. Species Crossreactivity: human. Does not crossreact with human MDR1, MRP1, MRP2 or MRP5 gene products.

purity :

Supernatant. Supernatant

form :

Supplied as a liquid, 0.7% BSA, 0.1% sodium azide.

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

app notes :

Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Flow Cytometry. Dilution: Western Blot: 1:20-1:50 using a secondary antibody conjugated to HRP. Immnocytochemistry: 1:20-1:50 on acetone or formaldehyde fixed cytospin preparations. Immunohistochemistry (Frozen): 1:20 on acetone fixed frozen sections.

other info1 :

Immunogen: Bacterial fusion protein corresponding to aa830-949 of MRP3.

other info2 :

Hybridoma: Sp2/0 myeloma cells with lymph node cells from Balb/c mice.

products categories :

Antibodies; Abs to Multi Drug Resistance (MDR)

products description :

MRP3 is a 190-200kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M4688-23B has potential vaule for the detection of MRP3-mediated drug-resistance in human tumor samples.

ncbi gi num :

4102188

uniprot acc num :

O15438

ncbi mol weight :

169,343 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Bile Acid And Bile Salt Metabolism Pathway (106144); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Codeine And Morphine Metabolism Pathway (198831); Fluoropyrimidine Activity Pathway (198778); Metabolism Of Lipids And Lipoproteins Pathway (160976); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Recycling Of Bile Acids And Salts Pathway (106149)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]

uniprot summary :

ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 17q22. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding. Biological Process: bile acid and bile salt transport; transport; bile acid metabolic process; transmembrane transport

size1 :

1 mL

price1 :

605 USD

more info or order :

MyBioSource product webpage