Complement C1q, Mouse | MyBioSource MBS631783 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Complement C1q, Mouse

catalog :

MBS631783

quantity :

0.1 mg

price :

745 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

[9j111]

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS631783

products type :

Antibody

products full name :

Complement C1q, Mouse

products short name :

[Complement C1q]

products name syn :

[Anti -Complement C1q, Mouse]

other names :

[complement C1q subcomponent subunit C; Complement C1q subcomponent subunit C; complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide; complement component 1, q subcomponent, C chain]

other gene names :

[C1QC; C1QC; C1QG; C1Q-C; C1QG]

uniprot entry name :

C1QC_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

[9j111]

host :

Rat

reactivity :

Mouse

specificity :

Recognizes mouse Complement C1q.

purity :

Affinity Purified. Purified by Protein A/G affinity chromatography.

form :

Supplied as a lyophilized powder from PBS, ph 7.4, 1mg/ml BSA. Reconsitute with 100ul sterile PBS.

concentration :

1mg/ml (after reconsitution)

storage stability :

Lyophilized and reconsituted products are stable for 12 months after receipt at -20 degree C. Reconsitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA), Western Blot (WB)

app notes :

Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:10,000-1:50,000. Western Blot: 1:1000-1:5000 (ECL). Optimal dilutions to be determined by the researcher.

other info1 :

Immunogen: Complement C1q, Mouse

products categories :

Antibodies; Abs to Complement

products description :

Acrp30 (adipocyte complement-related protein of 30kD), also known as AdipoQ, APM1, Adiponectin, Gelatin binding protein 28kD/GBP28 or adipocyte most abundant gene transcript) was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, Acrp30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. C1q is serum glycoprotein of 18-polypeptides chains consisting of three non-identical subunits, A (29kD), B (26kD), and C (246 aa, 19kD) in molar ratio of 1:2:2. C1Q in the plasma is complexed with two proenzymes C1r and two C1s molecule to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of globular head of C1q to immune complexes containing IgG (Fc-region) or IgM or to a variety of other activating substances, including C-reactive protein, retrovirus, and mitochondria. Subsequent to C1q binding, c1r and C1s are converted to proteolytic enzymes that are responsible to continuation of activation via the classical pathway.

ncbi gi num :

166235903

ncbi acc num :

NP_001107573.1

ncbi gb acc num :

NM_001114101.1

uniprot acc num :

P02747

ncbi mol weight :

25,774 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: extracellular space; collagen; extracellular region. Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; complement activation; negative regulation of granulocyte differentiation. Disease: C1q Deficiency

size1 :

0.1 mg

price1 :

745 USD

more info or order :

MyBioSource product webpage