product summary
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company name :
MyBioSource
product type :
antibody
product name :
AMOTL2, ID (Leman Coiled-coil Protein, LCCP, Angiomotin-like Protein 2, KIAA0989)
catalog :
MBS630554
quantity :
0.2 mL
price :
500 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, other
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS630554
products type :
Antibody
products full name :
AMOTL2, ID (Leman Coiled-coil Protein, LCCP, Angiomotin-like Protein 2, KIAA0989)
products short name :
AMOTL2
products name syn :
Anti -AMOTL2, ID (Leman Coiled-coil Protein, LCCP, Angiomotin-like Protein 2, KIAA0989)
other names :
AMOTL2 protein; AMOTL2 protein; angiomotin-like protein 2; OTTHUMP00000216465; OTTHUMP00000216466; OTTHUMP00000216530; OTTHUMP00000216978; Leman coiled-coil protein; angiomotin like 2
other gene names :
AMOTL2; LCCP
uniprot entry name :
Q8TBR8_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
specificity :
Recognizes human AMOTL2. Species Crossreactivity: mouse
purity :
Affinity Purified. Purified by Protein A affinity chromatography
form :
Supplied as a liquid in PBS, 0.09% sodium azide.
concentration :
0.53 mg/ml
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
Western Blot (WB). Other applications have not tested.
app notes :
Suitable for use in Western Blot. Dilution: Western Blot: 1:1000. Optimal dilutions to be determined by the researcher.
other info1 :
Immunogen: Synthetic peptide corresponding to a region near aa126-152 from the center region of human AMOTL2, conjugated to KLH. Species sequence homology: Bovine, Rat
products categories :
Antibodies; Abs to Binding Proteins
products description :
AMOTL2 is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
ncbi gi num :
33872302
uniprot acc num :
Q8TBR8
ncbi mol weight :
11,704 Da
ncbi pathways :
Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275)
ncbi summary :
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family. [provided by RefSeq]
uniprot summary :
AMOTL2: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion. Chromosomal Location of Human Ortholog: 3q21-q22. Cellular Component: recycling endosome; tight junction; apical plasma membrane; cytoplasmic vesicle; cytosol. Molecular Function: identical protein binding; protein binding. Biological Process: Wnt receptor signaling pathway
size1 :
0.2 mL
price1 :
500 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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