product summary
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company name :
MyBioSource
product type :
antibody
product name :
PHLPP2, NT (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)
catalog :
MBS628170
quantity :
0.2 mL
price :
500 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS628170
products type :
Antibody
products full name :
PHLPP2, NT (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)
products short name :
PHLPP2
products name syn :
Anti -PHLPP2, NT (PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, KIAA0931, PH Domain Leucine-rich Repeat-containing Protein Phosphatase-like, PHLPP-like, PHLPPL)
other names :
PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like
other gene names :
PHLPP2; PHLPP2; PHLPPL; KIAA0931; KIAA0931; PHLPPL
uniprot entry name :
PHLP2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
specificity :
Recognizes human PHLPP2.
purity :
Purified. Purified by ammonium sulfate precipitation.
form :
Supplied as a liquid in PBS, 0.09% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Western Blot (WB)
app notes :
Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1000. Western Blot: 1:50-1:100
other info1 :
Immunogen: Synthetic peptide corresponding to aa11-40 from the N-terminal region of human PHLPP2 conjugated to KLH.
products categories :
Antibodies; Abs to Enzymes, Phosphatase
products description :
PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.
ncbi gi num :
65301141
ncbi acc num :
NP_055835.2
ncbi gb acc num :
NM_015020.2
uniprot acc num :
Q6ZVD8
ncbi mol weight :
146,751 Da
uniprot summary :
PHLPP2: Protein phosphatase that mediates dephosphorylation of Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II and Ser- 657 of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser-473 of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.3.16; Tumor suppressor; Protein phosphatase, Ser/Thr (non-receptor). Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: photoreceptor inner segment; cytoplasm; cytosol; nucleus. Molecular Function: metal ion binding; protein serine/threonine phosphatase activity. Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; innate immune response; protein amino acid dephosphorylation
size1 :
0.2 mL
price1 :
500 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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