CrkRS, NT (Cell Division Protein Kinase 12, Cell Division Cycle 2-related Protein Kinase 7, CDC2-related Protein Kinase 7, Cdc2-related Kinase, Arginine/Serine-rich, CDK12, CRK7, CRKRS, KIAA0904) | MyBioSource MBS626394 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CrkRS, NT (Cell Division Protein Kinase 12, Cell Division Cycle 2-related Protein Kinase 7, CDC2-related Protein Kinase 7, Cdc2-related Kinase, Arginine/Serine-rich, CDK12, CRK7, CRKRS, KIAA0904)

catalog :

MBS626394

quantity :

0.2 mL

price :

610 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

The anti-CRK7 Pab is used in Western blot to detect CRK7 in mouse liver tissue lysate.

product information

catalog number :

MBS626394

products type :

Antibody

products full name :

CrkRS, NT (Cell Division Protein Kinase 12, Cell Division Cycle 2-related Protein Kinase 7, CDC2-related Protein Kinase 7, Cdc2-related Kinase, Arginine/Serine-rich, CDK12, CRK7, CRKRS, KIAA0904)

products short name :

[CrkRS]

products name syn :

[Anti -CrkRS, NT (Cell Division Protein Kinase 12, Cell Division Cycle 2-related Protein Kinase 7, CDC2-related Protein Kinase 7, Cdc2-related Kinase, Arginine/Serine-rich, CDK12, CRK7, CRKRS, KIAA0904)]

other names :

[cyclin-dependent kinase 12 isoform 2; Cyclin-dependent kinase 12; cyclin-dependent kinase 12; CDC2-related protein kinase 7; cell division protein kinase 12; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cyclin-dependent kinase 12; Cdc2-related kinase, arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12]

other gene names :

[CDK12; CDK12; CRK7; CRKR; CRKRS; hCDK12; CRK7; CRKRS; KIAA0904; CrkRS; CDC2-related protein kinase 7; hCDK12]

uniprot entry name :

CDK12_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

specificity :

Recognizes human CRK7. Species Crossreactivity: mouse.

purity :

Purified. Purified by ammonium sulfate precipitation.

form :

Supplied as a liquid in PBS, 0.09% sodium azide.

concentration :

2.1 mg/mL

storage stability :

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

ELISA (EL/EIA), Western Blot (WB). Other application not tested.

app notes :

Western Blot: 1:100. Optimal dilutions to be determined by the researcher.

image1 heading :

Western Blot (WB)

other info1 :

. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human CRK7. Species Sequence Homology:rat.

products categories :

Antibodies; Abs to Cell Division Cycle (CDC)

products description :

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

ncbi gi num :

157817073

ncbi acc num :

NP_055898.1

ncbi gb acc num :

NM_015083.1

uniprot acc num :

Q9NYV4

uniprot summary :

CDK12: a Ser/Thr protein kinase of the CMGC group and CDK family. Phosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Interacts with CCNL1 and CCNL2. Colocalized with nuclear speckles throughout interphase. Has a highly phosphorylated arginine/serine-rich (RS) domain N-terminal to the kinase domain. Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. Three isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Kinase, protein; Cell cycle regulation; EC 2.7.11.23; Protein kinase, CMGC; Spliceosome; EC 2.7.11.22; RNA splicing; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CRK7 subfamily; CDK/CRK7 subfamily. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: nucleoplasm; nuclear cyclin-dependent protein kinase holoenzyme complex; nucleolus; nuclear speck; nucleus. Molecular Function: RNA polymerase subunit kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity. Biological Process: regulation of cell cycle; protein amino acid autophosphorylation; regulation of MAP kinase activity; RNA splicing; mRNA processing

size1 :

0.2 mL

price1 :

610 USD

more info or order :

MyBioSource product webpage