catalog number :
MBS625744
products full name :
ALDH1L1, CT (Aldehyde Dehydrogenase Family 1 Member L1, 10-formyltetrahydrofolate Dehydrogenase, 10-FTHFDH, FTHFD)
products short name :
ALDH1L1
products name syn :
Anti -ALDH1L1, CT (Aldehyde Dehydrogenase Family 1 Member L1, 10-formyltetrahydrofolate Dehydrogenase, 10-FTHFDH, FTHFD)
other names :
aldehyde dehydrogenase family 1 member L1; Aldehyde dehydrogenase family 1 member L1; aldehyde dehydrogenase family 1 member L1; 10-FTHFDH; OTTHUMP00000155221; OTTHUMP00000214696; OTTHUMP00000214700; OTTHUMP00000222724; formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogenase; cytosolic 10-formyltetrahydrofolate dehydrogenase; aldehyde dehydrogenase 1 family, member L1; Cytosolic 10-formyltetrahydrofolate dehydrogenase
other gene names :
ALDH1L1; ALDH1L1; FDH; FTHFD; 10-fTHF; DKFZp781N0997; FTHFD
uniprot entry name :
AL1L1_HUMAN
reactivity :
Human, Mouse
specificity :
Recognizes human ALDH1L1. Species Crossreactivity: mouse
purity :
Purified. Purified by ammonium sulfate precipitation.
form :
Supplied as a liquid in PBS, 0.09% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1000. Western Blot: 1:50-1:100. Immunohistochemistry: 1:50-1:100
other info1 :
Immunogen: Synthetic peptide corresponding to a region between aa724-754 from the C-terminal region of human ALDH1L1, conjugated to KLH.
products categories :
Antibodies; Abs to Enzymes, Dehydrogenase
products description :
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
ncbi acc num :
NP_036322.2
ncbi gb acc num :
NM_012190.2
ncbi mol weight :
98,829 Da
ncbi pathways :
One Carbon Metabolism Pathway (198756); One Carbon Pool By Folate Pathway (83008); One Carbon Pool By Folate Pathway (393)
ncbi summary :
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning. [provided by RefSeq]
uniprot summary :
ALDH1L1: 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.6. Chromosomal Location of Human Ortholog: 3q21.3. Cellular Component: mitochondrion. Molecular Function: methyltransferase activity; aldehyde dehydrogenase (NAD) activity; hydroxymethyl-, formyl- and related transferase activity; formyltetrahydrofolate dehydrogenase activity; catalytic activity. Biological Process: methylation; biosynthetic process; one-carbon compound metabolic process; 10-formyltetrahydrofolate catabolic process