antibody

Glucose Regulated Protein 78 (Hspa5, Heat Shock Protein 5, 78kD, 78kD Glucose-Regulated Protein precursor, AL022860, AU019543, Bip, BiP, D2Wsu141e, D2Wsu17e, Grp78, GRP 78, Heat shock 70kD protein 5, Heat Shock 70kD Protein 5, Hsce70, Immunoglobulin

MBS621971

0.05 mL

435 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunocytochemistry

Antibody

Glucose Regulated Protein 78 (Hspa5, Heat Shock Protein 5, 78kD, 78kD Glucose-Regulated Protein precursor, AL022860, AU019543, Bip, BiP, D2Wsu141e, D2Wsu17e, Grp78, GRP 78, Heat shock 70kD protein 5, Heat Shock 70kD Protein 5, Hsce70, Immunoglobulin heavy

[Glucose Regulated Protein 78]

[Anti -Glucose Regulated Protein 78 (Hspa5, Heat Shock Protein 5, 78kD, 78kD Glucose-Regulated Protein precursor, AL022860, AU019543, Bip, BiP, D2Wsu141e, D2Wsu17e, Grp78, GRP 78, Heat shock 70kD protein 5, Heat Shock 70kD Protein 5, Hsce70, Immunoglobulin heavy]

[glucose-regulated protein 78; Luminal-binding protein; glucose-regulated protein 78; 78 kDa glucose-regulated protein homolog]

[BiP/grp78]

BIP_SOLLC

Polyclonal

IgG

Rabbit

Bovine, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus

Recognizes rat Glucose Regulated Protein 78. Species Crossreactivity: human, mouse, bovine, fungus (Cryphonectria parasitica), hamster, monkey, rabbit, canine and Xenopus

Serum

Supplied as a liquid.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorecence (IF), Immunocytochemistry (ICC)

Suitable for use in Western Blot. Dilution: Western Blot:1:2000 (ECL) 10ug of rat tissue lysate. Immunofluorescence/Immunocytochemistry: 1:100. Optimal dilutions to be determined by the researcher.

Grade: Serum: Immunogen: Synthetic peptide corresponding to rat Glucose Regulated Protein 78, conjugated to KLH.

Antibodies; Abs to Heat Shock Proteins

GRP78 is a ubiquitously expressed, 78kD glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimer’s patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs.

170384

NP_037215.1

P49118

Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Subcellular location: Endoplasmic reticulum lumen. Sequence similarities: Belongs to the heat shock protein 70 family.

0.05 mL

435 USD

0.2 mL

595