Activin Receptor Type IIB (RIIB) (Biotin) | MyBioSource MBS621317 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Activin Receptor Type IIB (RIIB) (Biotin)

catalog :

MBS621317

quantity :

0.05 mg

price :

835 USD

clonality :

polyclonal

host :

goat

conjugate :

biotin

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS621317

products type :

Antibody

products full name :

Activin Receptor Type IIB (RIIB) (Biotin)

products short name :

[Activin Receptor Type IIB]

products name syn :

[Anti -Activin Receptor Type IIB (RIIB) (Biotin)]

other names :

[activin receptor type IIB; Activin receptor type-2B; activin receptor type-2B; OTTHUMP00000161965; activin A receptor, type IIB; Activin receptor type IIB]

other gene names :

[ACVR2B; ACVR2B; HTX4; ACTRIIB; ActR-IIB; MGC116908]

uniprot entry name :

AVR2B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Human

specificity :

Recognizes rhActivin RIIB extracellular domain.

purity :

Affinity Purified. Purified by immunoaffinity chromatography.

form :

Supplied as a lyophilized powder from PBS, pH 7.4, 50ug BSA/1 ug protein. Labeled with Biotin. Reconstitute with 200 ul sterile PBS.

concentration :

~0.2 ug/ml (after reconstitution)

storage stability :

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 deg C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20 deg C. Reconstitued product is stable for 12 months at -20 deg C. For maximum recovery of product, certrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

Western Blot (WB)

app notes :

Suitable for use in Western Blot. Dilution: Western Blot: 0.1-0.2ug/ml

other info1 :

Immunogen: Recombinant protein corresponding to aa 19-134 from uman Activin Receptor Type-2B (CAA54671), express in NSO cells.

products categories :

Antibodies; Abs to Activin Receptors

ncbi gi num :

5731735

uniprot acc num :

Q13705

ncbi mol weight :

57,724 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Signaling By BMP Pathway (106336); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

uniprot summary :

ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor. Protein type: EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Kinase, protein; TKL group; STKR family; Type2 subfamily. Chromosomal Location of Human Ortholog: 3p22. Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex. Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; metal ion binding; growth factor binding; protein serine/threonine/tyrosine kinase activity; activin binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; pancreas development; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ growth; skeletal morphogenesis; insulin secretion; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development. Disease: Heterotaxy, Visceral, 4, Autosomal

size1 :

0.05 mg

price1 :

835 USD

more info or order :

MyBioSource product webpage