Urea Transporter A1 (Slc14a2. Solute carrier family 14 (urea transporter), member 2, Slc14a2T, Solute carrier family 14 member 2, Urea transporter, kidney, Urea transporter 2, UrT1-C, UrT1-D, Ut2) | MyBioSource MBS621227 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Urea Transporter A1 (Slc14a2. Solute carrier family 14 (urea transporter), member 2, Slc14a2T, Solute carrier family 14 member 2, Urea transporter, kidney, Urea transporter 2, UrT1-C, UrT1-D, Ut2)

catalog :

MBS621227

quantity :

0.1 mL

price :

590 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS621227

products type :

Antibody

products full name :

Urea Transporter A1 (Slc14a2. Solute carrier family 14 (urea transporter), member 2, Slc14a2T, Solute carrier family 14 member 2, Urea transporter, kidney, Urea transporter 2, UrT1-C, UrT1-D, Ut2)

products short name :

[Urea Transporter A1]

products name syn :

[Anti -Urea Transporter A1 (Slc14a2. Solute carrier family 14 (urea transporter), member 2, Slc14a2T, Solute carrier family 14 member 2, Urea transporter, kidney, Urea transporter 2, UrT1-C, UrT1-D, Ut2)]

other names :

[urea transporter 2; Urea transporter 2; urea transporter 2; urea transporter-2; urea transporter, kidney; solute carrier family 14 member 2; solute carrier family 14 (urea transporter), member 2; Solute carrier family 14 member 2; Urea transporter, kidney]

other gene names :

[SLC14A2; SLC14A2; UT2; UTA; UTR; HUT2; UT-A2; hUT-A6; HUT2; UT2]

uniprot entry name :

UT2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

Recognizes rat UT-A1 at ~97kD and 127 kD. Species Crossreactivity: mouse.

purity :

Affinity by Purified Chromatography

form :

Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.

concentration :

1mg/ml

storage stability :

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

tested application :

Western Blot (WB), Immunocytochemistry (ICC)

app notes :

Suitable for use in Western Blot and Immunocytochemistry. Dilution: . Western Blot: 1:1000. 1ug/ml detected UT-A1 in 20 ug of rat kidney tissue lysate by colorimetric immunoblot analysis using IgG goat x rabbit (HRP) as the secondary antibody. Optimal diluitons to be determined by the researcher.

other info1 :

Immunogen: Synthetic peptide corresponding to aa911-929 of the C-terminal tail of rat UT-A1 (NP_062220).

products categories :

Antibodies; Abs to Transport Proteins

products description :

UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates transepithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promotor and expressed in the thin descending limb of Henle, viz. UT-A2).

ncbi gi num :

336594532

ncbi acc num :

NP_001229621.1

ncbi gb acc num :

NM_001242692.1

uniprot acc num :

Q15849

ncbi pathways :

SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

ncbi summary :

The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

uniprot summary :

SLC14A2: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Belongs to the urea transporter family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 18q12.1-q21.1. Cellular Component: membrane; apical plasma membrane; integral to membrane; plasma membrane. Molecular Function: protein binding; urea transmembrane transporter activity; cell adhesion molecule binding. Biological Process: urea transport; transmembrane transport

size1 :

0.1 mL

price1 :

590 USD

more info or order :

MyBioSource product webpage